Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL015491-16
Application #
3334966
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1976-05-01
Project End
1991-04-30
Budget Start
1988-05-01
Budget End
1989-04-30
Support Year
16
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
City
San Diego
State
CA
Country
United States
Zip Code
92037
Ikeda, Y; Handa, M; Kawano, K et al. (1991) The role of von Willebrand factor and fibrinogen in platelet aggregation under varying shear stress. J Clin Invest 87:1234-40
Sugimoto, M; Ricca, G; Hrinda, M E et al. (1991) Functional modulation of the isolated glycoprotein Ib binding domain of von Willebrand factor expressed in Escherichia coli. Biochemistry 30:5202-9
Sugimoto, M; Mohri, H; McClintock, R A et al. (1991) Identification of discontinuous von Willebrand factor sequences involved in complex formation with botrocetin. A model for the regulation of von Willebrand factor binding to platelet glycoprotein Ib. J Biol Chem 266:18172-8
Fujimura, Y; Titani, K; Usami, Y et al. (1991) Isolation and chemical characterization of two structurally and functionally distinct forms of botrocetin, the platelet coagglutinin isolated from the venom of Bothrops jararaca. Biochemistry 30:1957-64
Dent, J A; Galbusera, M; Ruggeri, Z M (1991) Heterogeneity of plasma von Willebrand factor multimers resulting from proteolysis of the constituent subunit. J Clin Invest 88:774-82
Ware, J; Dent, J A; Azuma, H et al. (1991) Identification of a point mutation in type IIB von Willebrand disease illustrating the regulation of von Willebrand factor affinity for the platelet membrane glycoprotein Ib-IX receptor. Proc Natl Acad Sci U S A 88:2946-50
De Marco, L; Mazzucato, M; De Roia, D et al. (1990) Distinct abnormalities in the interaction of purified types IIA and IIB von Willebrand factor with the two platelet binding sites, glycoprotein complexes Ib-IX and IIb-IIIa. J Clin Invest 86:785-92
Dent, J A; Berkowitz, S D; Ware, J et al. (1990) Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor. Proc Natl Acad Sci U S A 87:6306-10
Vicente, V; Houghten, R A; Ruggeri, Z M (1990) Identification of a site in the alpha chain of platelet glycoprotein Ib that participates in von Willebrand factor binding. J Biol Chem 265:274-80
Foster, P A; Zimmerman, T S (1989) Factor VIII structure and function. Blood Rev 3:180-91

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