Abstract

The goals of this project are to improve our understanddng of membrane function at a molecular level through analyses of the specificities of interactions among the principal membrane components. Phosphatidylcholine analogs will be synthesized having variations in the structure of the polar region. The interactions of these analogs with the D-beta-hydroxybutyrate dehydrogenase calcium pump protein, phospholipid exchange protein, and cholesterol will be studied by biophysical techniques.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL016660-12
Application #
3335246
Study Section
Biophysics and Biophysical Chemistry B Study Section (BBCB)
Project Start
1977-05-01
Project End
1986-03-31
Budget Start
1985-04-01
Budget End
1986-03-31
Support Year
12
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Queens College
Department
Type
Schools of Arts and Sciences
DUNS #
City
Flushing
State
NY
Country
United States
Zip Code
11367

  Publications

Li, Zaiguo; Baker, Daniel L; Tigyi, Gabor et al. (2006) Synthesis of photoactivatable analogues of lysophosphatidic acid and covalent labeling of plasma proteins. J Org Chem 71:629-35
Lu, Xuequan; Bittman, Robert (2005) Synthesis of a photoactivatable (2S,3R)-sphingosylphosphorylcholine analogue. J Org Chem 70:4746-50
Malewicz, Barbara; Valiyaveettil, Jacob T; Jacob, Kochurani et al. (2005) The 3-hydroxy group and 4,5-trans double bond of sphingomyelin are essential for modulation of galactosylceramide transmembrane asymmetry. Biophys J 88:2670-80
Waarts, Barry-Lee; Aneke, Onwuchekwa J C; Smit, Jolanda M et al. (2005) Antiviral activity of human lactoferrin: inhibition of alphavirus interaction with heparan sulfate. Virology 333:284-92
Lu, Xuequan; Byun, Hoe-Sup; Bittman, Robert (2004) Synthesis of l-lyxo-phytosphingosine and its 1-phosphonate analogue using a threitol acetal synthon. J Org Chem 69:5433-8
Li, Zaiguo; Mintzer, Evan; Bittman, Robert (2004) The critical micelle concentrations of lysophosphatidic acid and sphingosylphosphorylcholine. Chem Phys Lipids 130:197-201
Brockman, Howard L; Momsen, Maureen M; Brown, Rhoderick E et al. (2004) The 4,5-double bond of ceramide regulates its dipole potential, elastic properties, and packing behavior. Biophys J 87:1722-31
Sun, Chaode; Bittman, Robert (2004) An efficient preparation of isosteric phosphonate analogues of sphingolipids by opening of oxirane and cyclic sulfamidate intermediates with alpha-lithiated alkylphosphonic esters. J Org Chem 69:7694-9
Johnson, Charlene R; Chun, Jiong; Bittman, Robert et al. (2004) Intrinsic cytotoxicity and chemomodulatory actions of novel phenethylisothiocyanate sphingoid base derivatives in HL-60 human promyelocytic leukemia cells. J Pharmacol Exp Ther 309:452-61
McInerney, Gerald M; Smit, Jolanda M; Liljestrom, Peter et al. (2004) Semliki Forest virus produced in the absence of the 6K protein has an altered spike structure as revealed by decreased membrane fusion capacity. Virology 325:200-6

Showing the most recent 10 out of 81 publications