It is our long-term goal to develop an understanding of the role of humoral factors, particularly vasopressin (VP), in the pathogenesis of hypertension. Our recent finding that deoxycorticosterone (DOC)-salt hypertension develops much more slowly in male than in female rats was, then, of particular interest to us since DOC- salt hypertension is dependent upon VP and since pressor responsiveness to VP is higher in male rats than in female rats in most phases of the estrous cycle. In this application, we propose to explore the hemodynamic, humoral, and renal mechanisms underlying the sexual dimorphism of DOC-salt hypertension in the rat as follows. 1) We shall characterize the hemodynamic and humoral differences between male and female rats in the development of DOC-salt hypertension. 2) We shall determine the role of the gonadal steroid hormones in the sexual dimorphism of DOC-salt hypertension. 3) We shall determine the role of the kidney in the sexual dimorphism of DOC-salt hypertension. 4) We shall determine whether there is a sexual dimorphism in DOC-salt hypertension when DOC is given centrally. 5) We shall determine whether sexual dimorphism occurs in other, non-genetic experimental models of hypertension, e.g., two-kidney one-clip hypertension and partial nephrectomy-salt hypertension. This research is relevant to the well known observation that the incidence of hypertension is lower in pre-menopausal women than in men.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL019209-12
Application #
3563694
Study Section
Cardiovascular and Pulmonary Research B Study Section (CVB)
Project Start
1976-06-01
Project End
1992-06-30
Budget Start
1987-07-01
Budget End
1988-06-30
Support Year
12
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Tennessee Health Science Center
Department
Type
DUNS #
941884009
City
Memphis
State
TN
Country
United States
Zip Code
38163
He, X R; Wang, W; Crofton, J T et al. (1999) Effects of 17beta-estradiol on the baroreflex control of sympathetic activity in conscious ovariectomized rats. Am J Physiol 277:R493-8
He, X R; Wang, W; Crofton, J T et al. (1998) Effects of 17beta-estradiol on sympathetic activity and pressor response to phenylephrine in ovariectomized rats. Am J Physiol 275:R1202-8
Crofton, J T; Share, L (1997) Gonadal hormones modulate deoxycorticosterone-salt hypertension in male and female rats. Hypertension 29:494-9
Wang, Y X; Crofton, J T; Share, L (1997) Sex differences in the cardiovascular and renal actions of vasopressin in conscious rats. Am J Physiol 272:R370-6
Wang, Y X; Crofton, J T; Bealer, S L et al. (1997) Sexual dimorphism in regional blood flow responses to vasopressin in conscious rats. Am J Physiol 273:R1126-31
Wang, Y X; Crofton, J T; Liu, H et al. (1996) V2-receptor blockade enhances pressor response to vasopressin: gender difference. Life Sci 59:695-703
Wang, Y X; Crofton, J T; Miller, J et al. (1996) Sex difference in urinary concentrating ability of rats with water deprivation. Am J Physiol 270:R550-5
Liu, H W; Wang, Y X; Crofton, J T et al. (1996) Central vasopressin blockade enhances its peripheral release in response to peripheral osmotic stimulation in conscious rats. Brain Res 719:14-22
Wang, Y X; Crofton, J T; Liu, H et al. (1995) Estradiol attenuates the antidiuretic action of vasopressin in ovariectomized rats. Am J Physiol 268:R951-7
Sato, K; Crofton, J T; Wang, Y X et al. (1995) Effects of gender on the central actions of neuropeptide Y and norepinephrine on vasopressin and blood pressure in the rat. Brain Res 689:71-8

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