Abstract

We are studying mechanisms of inflammatory lung disease, induced by inhaled substances. We employ an animal model in which antigens and mitogens (polyclonal cell activators) are administered in aerosol form. It is anticipated that we will be able to define the roles of cell-mediated immunity, antibody-mediated immunity, and polyclonal cell activation in environmental lung disease, using this model.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL019819-09
Application #
3335959
Study Section
Pathology A Study Section (PTHA)
Project Start
1979-06-01
Project End
1987-03-31
Budget Start
1986-06-01
Budget End
1987-03-31
Support Year
9
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Lamb Jr, L S; Willoughby, J B; Willoughby, W F (1995) Morphologic and functional characteristics of alveolar macrophages following cryopreservation. Cryobiology 32:344-57
Gerberick, G F; Jaffe, H A; Willoughby, J B et al. (1986) Relationships between pulmonary inflammation, plasma transudation, and oxygen metabolite secretion by alveolar macrophages. J Immunol 137:114-21
Gerberick, G F; Willoughby, J B; Willoughby, W F (1985) Serum factor requirement for reactive oxygen intermediate release by rabbit alveolar macrophages. J Exp Med 161:392-408
Willoughby, W F; Willoughby, J B; Gerberick, G F (1985) Polyclonal activators in pulmonary immune disease. Clin Rev Allergy 3:197-216