Abstract

It is well recognized that atherosclerosis is a major medical problem which involves major arteries supplying the heart, the brain and the extremities. It has been possible with the development of ultrasonic techniques to evaluate the location and extent of the involvement in the carotid and peripheral arteries. Since the method is noninvasive, painless and safe, it has been possible to utilize the combination of pulse echo and Doppler methods to assess the degree of narrowing at the time of the examination and to follow changes in the disease during follow-up. It is proposed to further develop these methods to employ the use of computerized pattern recognition which will permit quantification of information present in the Doppler spectrum to predict the degree of stenosis. In addition to providing a more objective assessment of the degree of stenosis, the ultrasonic duplex method will be used to assess the prevalence of restenosis after carotid endarterectomy and its relevance to the development of clinical events such as transient ischemic attacks and strokes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL020898-11
Application #
3336306
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1986-09-08
Project End
1991-08-31
Budget Start
1988-09-08
Budget End
1989-08-31
Support Year
11
Fiscal Year
1988
Total Cost
Indirect Cost

  Institution

Name
University of Washington
Department
Type
Schools of Medicine
DUNS #
135646524
City
Seattle
State
WA
Country
United States
Zip Code
98195

  Publications

Johnson, B F; Verlato, F; Bergelin, R O et al. (1995) Clinical outcome in patients with mild and moderate carotid artery stenosis. J Vasc Surg 21:120-6
Edwards, J M; Zaccardi, M J; Strandness Jr, D E (1992) A preliminary study of the role of duplex scanning in defining the adequacy of treatment of patients with renal artery fibromuscular dysplasia. J Vasc Surg 15:604-9;discussion 609-11
Edwards, J M; Coldwell, D M; Goldman, M L et al. (1991) The role of duplex scanning in the selection of patients for transluminal angioplasty. J Vasc Surg 13:69-74
Hoffmann, U; Edwards, J M; Carter, S et al. (1991) Role of duplex scanning for the detection of atherosclerotic renal artery disease. Kidney Int 39:1232-9
Nicholls, S C; Koutlas, T C; Strandness, D E (1991) Clinical significance of retrograde flow in the vertebral artery. Ann Vasc Surg 5:331-6
Schrank, E; Phillips, D J; Moritz, W E et al. (1990) A triangulation method for the quantitative measurement of arterial blood velocity magnitude and direction in humans. Ultrasound Med Biol 16:499-509
Phillips, D J; Hossack, J; Beach, K W et al. (1990) Testing ultrasonic pulsed Doppler instruments with a physiologic string phantom. J Ultrasound Med 9:429-36
Phillips, D J (1990) Recent advances in carotid artery evaluation. Clin Diagn Ultrasound 26:25-44
Hatsukami, T S; Healy, D A; Primozich, J F et al. (1990) Fate of the carotid artery contralateral to endarterectomy. J Vasc Surg 11:244-50;discussion 250-1
Kohler, T R; Andros, G; Porter, J M et al. (1990) Can duplex scanning replace arteriography for lower extremity arterial disease? Ann Vasc Surg 4:280-7

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