Abstract

For the last five years I have worked to analyze the control system that regulates potassium. This analysis will continue, with the functions of the different components analyzed separately under uniform conditions so that the data may be combined. A mathematical model of the control system has been developed and will be expanded for use in developing and testing hypotheses. Factors important in short-term potassium regulation will be studied experimentally including: 1) effects of the Beta-adrenergic system on K regulation, 2) interaction between the K control system and the insulin-glucose control system, 3) interactions between plasma K and angiotensin II in aldo-sterone regulation, 4) and time courses of action of factors affecting K distribution and excretion. The analysis of effects of changes in plasma K and K balance on renal and cardiovascular function will continue. The following areas will be studied: effects of sustained changes in K on 1) pumping ability of the heart, 2) neural control of the circulation, 3) control of vascular smooth muscle, 4) renal function, 5) blood pressure regulation, 6) osmotic regulation, and 7) glucose regulation. Currently, there is only a rudimentary understanding of K regulation and the effects of abnormal K concentration on the major organ systems. The results of the projects proposed herein will provide information and understanding in these areas which will improve management of a large portion of the health care problems of the nation, including heart disease, hypertension, diabetes mellitus, surgical stress and numerous conditions associated with old age.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL021435-07A2
Application #
3336492
Study Section
Cardiovascular and Pulmonary Research B Study Section (CVB)
Project Start
1977-09-01
Project End
1989-11-30
Budget Start
1984-12-01
Budget End
1985-11-30
Support Year
7
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
University of Mississippi Medical Center
Department
Type
Schools of Medicine
DUNS #
928824473
City
Jackson
State
MS
Country
United States
Zip Code
39216

  Publications

Ma, G; Srivastava, N T; Anderson, P G et al. (2001) Elevated potassium intake inhibits neointimal proliferation in the swine coronary artery. Am J Hypertens 14:879-86
Ma, G; Young, D B; Clower, B R et al. (2000) High potassium intake inhibits neointima formation in the rat carotid artery balloon injury model. Am J Hypertens 13:1014-20
Lin, H; Smith Jr, M J; Young, D B (1996) Roles of prostaglandins and nitric oxide in the effect of endothelin-1 on renal hemodynamics. Hypertension 28:372-8
Young, D B; Lin, H; McCabe, R D (1995) Potassium's cardiovascular protective mechanisms. Am J Physiol 268:R825-37
Lin, H; Young, D B (1995) Opposing effects of plasma epinephrine and norepinephrine on coronary thrombosis in vivo. Circulation 91:1135-42
McCabe, R D; Bakarich, M A; Srivastava, K et al. (1994) Potassium inhibits free radical formation. Hypertension 24:77-82
Lin, H; Young, D B (1994) Interaction between plasma potassium and epinephrine in coronary thrombosis in dogs. Circulation 89:331-8
McCabe, R D; Young, D B (1994) Potassium inhibits cultured vascular smooth muscle cell proliferation. Am J Hypertens 7:346-50
Lin, H; Sangmal, M; Smith Jr, M J et al. (1993) Effect of endothelin-1 on glomerular hydraulic pressure and renin release in dogs. Hypertension 21:845-51
Young, D B; Srivastava, T N; Fitzovich, D E et al. (1992) Potassium and catecholamine concentrations in the immediate post exercise period. Am J Med Sci 304:150-3

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