Abstract

This study is directed toward obtaining a better understanding of the blood-materials interaction in human synthetic vascular grafts. Sensitive, specific and quantitative tests to detect thrombin formation, thrombin action and platelet activation in patients receiving vascular grafts will be used to determine hemostatic variations resulting from the acute phase of the blood-materials interaction. Correlative analyses of preclotted grafts and in vitro studies of blood and its components with clean, preclotted and retrieved grafts will be carried out. These studies will permit elucidation of the early phase of the blood-materials interaction of a clinically efficacious material. In human vascular grafts, the composition and extent of pseudointima will be determined with special attention directed toward the relationship with the extent and patterns of endothelialization and fibrinolytic activity. An integrated program, which makes use of the computer data bank of the Cleveland Vascular Society, will permit prospective and retrospective studies of human vascular grafts.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL027277-05
Application #
3339049
Study Section
(SSS)
Project Start
1981-09-15
Project End
1987-08-31
Budget Start
1985-09-01
Budget End
1987-08-31
Support Year
5
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Case Western Reserve University
Department
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106

  Publications

Ratnoff, O D; Everson, B; Embury, P et al. (1991) Inhibition of the activation of Hageman factor (factor XII) by human vascular endothelial cell culture supernates. Proc Natl Acad Sci U S A 88:10740-3
Bonfield, T L; Colton, E; Anderson, J M (1991) Fibroblast stimulation by monocytes cultured on protein adsorbed biomedical polymers. I. Biomer and polydimethylsiloxane. J Biomed Mater Res 25:165-75
Schmitz-Rixen, T; Megerman, J; Anderson, J M et al. (1991) Longterm study of a compliant biological vascular graft. Eur J Vasc Surg 5:149-58
Pankowsky, D A; Ziats, N P; Topham, N S et al. (1990) Morphologic characteristics of adsorbed human plasma proteins on vascular grafts and biomaterials. J Vasc Surg 11:599-606
Ziats, N P; Pankowsky, D A; Tierney, B P et al. (1990) Adsorption of Hageman factor (factor XII) and other human plasma proteins to biomedical polymers. J Lab Clin Med 116:687-96
Anderson, J M; Bonfield, T L; Ziats, N P (1990) Protein adsorption and cellular adhesion and activation on biomedical polymers. Int J Artif Organs 13:375-82
Miller, K M; Rose-Caprara, V; Anderson, J M (1989) Generation of IL-1-like activity in response to biomedical polymer implants: a comparison of in vitro and in vivo models. J Biomed Mater Res 23:1007-26
Bonfield, T L; Colton, E; Anderson, J M (1989) Plasma protein adsorbed biomedical polymers: activation of human monocytes and induction of interleukin 1. J Biomed Mater Res 23:535-48
Miller, K M; Huskey, R A; Bigby, L F et al. (1989) Characterization of biomedical polymer-adherent macrophages: interleukin 1 generation and scanning electron microscopy studies. Biomaterials 10:187-96
Kottke-Marchant, K; Anderson, J M; Umemura, Y et al. (1989) Effect of albumin coating on the in vitro blood compatibility of Dacron arterial prostheses. Biomaterials 10:147-55

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