The overall goal of this project is to describe secular trends in cardiovascular risk factors in the adolescent and adult U.S. population and to identify and quantify the changes in the variables related to these risk factors. A parallel goal is to modify and implement the statistical methodology available for the analysis of complex sample survey data in order to model and test these secular trends across separate nationally representative databases. The contemporaneous differences in risk factors in these nationally representative samples will be contrasted with those from a special population group, Hispanic Americans. To accomplish this goal, we will analyze data collected in nationally representative cross-sectional samples of the U.S. population to address the following 8 specific aims: 1) Describe trends in blood pressure, serum lipids and cigarette smoking in nationally representative samples of adolescents (12-17 years) and young adults (18-34 years) using data from surveys conducted from 1960 to 1984 by the National Center for Health Statistics (NCHS); 2) Describe the trends in blood pressure, serum lipids, cigarette smoking and obesity in nationally representative samples of older adults (35-75 years) using data from surveys conducted from 1960 to 1984 by NCHS; 3) Contrast the secular trends in these risk factors by subgrouping of age, race, sex, family income and educational attainment; 4) Determine the correlates of these risk factors and identify and quantify secular changes in these correlates over time; 5) Contrast contemporaneous values for risk factors and their correlates in the national population sample with the three Hispanic populations surveyed in the HHANES; In order to carry out these specific aims, we also propose to modify and refine statistical methodologies available for the analysis of complex sample survey data.
These aims i nclude 6) Implement, modify and compare recently developed statistical software for the analysis of complex sample survey data; 7) Investigate and compare alternative variational model fitting strategies to characterize the secular trends across the four national surveys; 8) Provide guidelines in the choice of analytical strategies to characterize secular trends across these nationally representative cross-sectional samples.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL033407-06
Application #
3345298
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1984-12-01
Project End
1989-11-30
Budget Start
1988-12-01
Budget End
1989-11-30
Support Year
6
Fiscal Year
1989
Total Cost
Indirect Cost
Name
Pennsylvania State University
Department
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033
Kumanyika, S K; Landis, J R; Matthews-Cook, Y L et al. (1998) Systolic blood pressure trends in US adults between 1960 and 1980: influence of antihypertensive drug therapy. Am J Epidemiol 148:528-38
Basu, S; Landis, J R (1995) Model-based estimation of population attributable risk under cross-sectional sampling. Am J Epidemiol 142:1338-43
Kumanyika, S K; Landis, J R; Matthews, Y L et al. (1994) Secular trends in blood pressure among adult blacks and whites aged 18-34 years in two body mass index strata, United States, 1960-1980. Am J Epidemiol 139:141-54
Miller, M E; Davis, C S; Landis, J R (1993) The analysis of longitudinal polytomous data: generalized estimating equations and connections with weighted least squares. Biometrics 49:1033-44
Heitjan, D F (1993) Ignorability and coarse data: some biomedical examples. Biometrics 49:1099-109
Harlan, W R; Landis, J R; Flegal, K M et al. (1988) Secular trends in body mass in the United States, 1960-1980. Am J Epidemiol 128:1065-74
Flegal, K M; Harlan, W R; Landis, J R (1988) Secular trends in body mass index and skinfold thickness with socioeconomic factors in young adult women. Am J Clin Nutr 48:535-43
Landis, J R; Flegal, K M (1988) A generalized Mantel-Haenszel analysis of the regression of blood pressure on blood lead using NHANES II data. Environ Health Perspect 78:35-41
Flegal, K M; Harlan, W R; Landis, J R (1988) Secular trends in body mass index and skinfold thickness with socioeconomic factors in young adult men. Am J Clin Nutr 48:544-51
Harlan, L C; Harlan, W R; Landis, J R et al. (1987) Factors associated with glucose tolerance in adults in the United States. Am J Epidemiol 126:674-84

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