Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL034688-04
Application #
3347858
Study Section
Pathology A Study Section (PTHA)
Project Start
1988-03-01
Project End
1990-08-31
Budget Start
1988-06-01
Budget End
1988-08-31
Support Year
4
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of California Irvine
Department
Type
Schools of Medicine
DUNS #
161202122
City
Irvine
State
CA
Country
United States
Zip Code
92697
Sindhu, R K; Sakai, H; Kikkawa, Y (2000) Effect of hyperoxia on rat pulmonary and hepatic cytochrome P450 monooxygenases. Arch Toxicol 73:540-6
Sindhu, R K; Mautz, W J; Kikkawa, Y (1998) Chronic exposure to ozone and nitric acid vapor results in increased levels of rat pulmonary putrescine. Arch Toxicol 72:445-9
Sindhu, R K; Rasmussen, R E; Kikkawa, Y (1996) Exposure to environmental tobacco smoke results in an increased production of (+)-anti-benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide in juvenile ferret lung homogenates. J Toxicol Environ Health 47:523-34
Sindhu, R K; Sakai, H; Okamoto, T et al. (1996) Differential effect of interleukin-1 alpha on rat hepatic cytochrome P450 monooxygenases. Toxicology 114:37-46
Sindhu, R K; Rasmussen, R E; Yamamoto, R et al. (1995) Depression of hepatic cytochrome P450 monooxygenases after chronic environmental tobacco smoke exposure of young ferrets. Toxicol Lett 76:227-38
Sindhu, R K; Rasmussen, R E; Kikkawa, Y (1995) Effect of environmental tobacco smoke on the metabolism of (-)-trans-benzo[a]pyrene-7,8-dihydrodiol in juvenile ferret lung and liver. J Toxicol Environ Health 45:453-64
Sindhu, R K; Kikkawa, Y (1995) Metabolism of (+)-trans-benzo[a]pyrene-7,8-dihydrodiol by 3-methylcholanthrene-induced rat liver homogenates. Toxicol Lett 81:5-13
Fujita, I; Sindhu, R K; Kikkawa, Y (1995) Hepatic cytochrome P450 enzyme imprinting in adult rat by neonatal benzo[a]pyrene administration. Pediatr Res 37:646-51
Kikkawa, Y; Fujita, I; Sindhu, R K (1994) Neonatal hyperoxia and cytochrome P450 imprinting in adulthood. Pediatr Res 35:255-8
Okamoto, T; Mitsuhashi, M; Fujita, I et al. (1993) Induction of cytochrome P450 1A1 and 1A2 by hyperoxia. Biochem Biophys Res Commun 197:878-85

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