Abstract

A novel magnetic imaging system using time-varying gradients is proposed for the imaging and characterization of atherosclerotic plaque. A sequence of signals are received in the presence of time-varying gradients in all three dimensions. From these signals, high-resolution three-dimensional image information can be derived to provide detailed anatomic information on the geometric structure of the plaque. In addition, these same signals can be further processed to derive specific spectroscopic data on relevant biochemical parameters of the plaque. Using a novel approach to spectral estimation, images are derived of these relevant parameters. Phantoms, animal models and human subjects will be used to verify the derived images with the actual plaque distribution. In vitro NMR will be used with excised plaque to study the spectroscopic characteristics of various forms of plaque and correlate them with the derived spectroscopic images.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL034962-02
Application #
3348379
Study Section
(SRC)
Project Start
1985-09-30
Project End
1988-09-29
Budget Start
1986-09-30
Budget End
1987-09-29
Support Year
2
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Stanford University
Department
Type
DUNS #
800771545
City
Stanford
State
CA
Country
United States
Zip Code
94305

  Publications

Plevritis, S K; Macovski, A (1995) MRS imaging using anatomically based k-space sampling and extrapolation. Magn Reson Med 34:686-93
Gold, G E; Pauly, J M; Glover, G H et al. (1993) Characterization of atherosclerosis with a 1.5-T imaging system. J Magn Reson Imaging 3:399-407
Hu, B S; Conolly, S M; Wright, G A et al. (1992) Pulsed saturation transfer contrast. Magn Reson Med 26:231-40
Wang, S J; Nishimura, D G; Macovski, A (1992) Fast angiography using selective inversion recovery. Magn Reson Med 23:109-21
Noll, D C; Pauly, J M; Meyer, C H et al. (1992) Deblurring for non-2D Fourier transform magnetic resonance imaging. Magn Reson Med 25:319-33
Jackson, J I; Nishimura, D G; Macovski, A (1992) Twisting radial lines with application to robust magnetic resonance imaging of irregular flow. Magn Reson Med 25:128-39
Webb, P; Spielman, D; Macovski, A (1992) Inhomogeneity correction for in vivo spectroscopy by high-resolution water referencing. Magn Reson Med 23:1-11
Webb, P; Macovski, A (1991) Rapid, fully automatic, arbitrary-volume in vivo shimming. Magn Reson Med 20:113-22
Spielman, D; Meyer, C; Macovski, A et al. (1991) 1H spectroscopic imaging using a spectral-spatial excitation pulse. Magn Reson Med 18:269-79
Wang, S J; Nishimura, D G; Macovski, A (1991) Multiple-readout selective inversion recovery angiography. Magn Reson Med 17:244-51

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