Aplastic anemia is believed to be a disease of high incidence in the Orient. However, no population-based study yet exists to verify this belief. It is proposed to conduct such an incidence study in metropolitan Bangkok in a manner which will yield valid comparisons with the few western studies of aplastic anemia incidence. Aplastic anemia is a disease of largely unknown etiology. While some evidence exists that occasional cases may be the result of short and long term side effects of a certain drugs and chemicals, such associations have not been consistently observed. In the United States and other developed countries the disease prevalence is low to such a degree that too few cases cluster in space and time to render epidemiologic study in a single city logistically feasible. The Bangkok hospitalization rate for aplastic anemia is sufficient to conduct a sound case-control study of this disease. Furthermore, a study conducted in this locale would provide information on drugs and chemicals not commonly in use in developed countries. Therefore, the second component of this proposal is a study of the epidemiology of aplastic anemia using the case-control design. Cases will be patients with aplastic anemia from Siriraj Hospital and all other hospitals in metropolitan Bangkok. Controls will be selected from patients with trauma and other acute conditions from the same hospital, broadly matched with cases for age, sex and the time of hospitalization. There will be 100 cases and 400 controls. Each subject will be interviewed using a standardized questionnaire. Data will be obtained on exposures to drugs, pesticides, chemicals, radiation, and viral infections. In addition, the proportions having evidence of recent hepatitis for cases and appropriate controls will be compared.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL035068-01A2
Application #
3348587
Study Section
Epidemiology and Disease Control Subcommittee 3 (EDC)
Project Start
1988-09-30
Project End
1991-09-29
Budget Start
1988-09-30
Budget End
1989-09-29
Support Year
1
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Mahidol University
Department
Type
DUNS #
City
Nakhon Pathom
State
Country
Thailand
Zip Code
73170
Issaragrisil, Surapol; Kaufman, David W; Anderson, Theresa et al. (2006) The epidemiology of aplastic anemia in Thailand. Blood 107:1299-307
Shapiro, S; Issaragrisil, S; Kaufman, D W et al. (1999) Agranulocytosis in Bangkok, Thailand: a predominantly drug-induced disease with an unusually low incidence. Aplastic Anemia Study Group. Am J Trop Med Hyg 60:573-7
Issaragrisil, S; Leaverton, P E; Chansung, K et al. (1999) Regional patterns in the incidence of aplastic anemia in Thailand. The Aplastic Anemia Study Group. Am J Hematol 61:164-8
Issaragrisil, S (1999) Epidemiology of aplastic anemia in Thailand. Thai Aplastic Anemia Study Group. Int J Hematol 70:137-40
Issaragrisil, S; U-pratya, Y; Yimyam, M et al. (1998) Hematopoietic progenitor cells in the blood and bone marrow in various hematologic disorders. Stem Cells 16 Suppl 1:123-8
Wiholm, B E; Kelly, J P; Kaufman, D et al. (1998) Relation of aplastic anaemia to use of chloramphenicol eye drops in two international case-control studies. BMJ 316:666
Kaufman, D W; Issaragrisil, S; Anderson, T et al. (1997) Use of household pesticides and the risk of aplastic anaemia in Thailand. The Aplastic Anemia Study Group. Int J Epidemiol 26:643-50
Issaragrisil, S; Kaufman, D; Thongput, A et al. (1997) Association of seropositivity for hepatitis viruses and aplastic anemia in Thailand. Hepatology 25:1255-7
Issaragrisil, S; Chansung, K; Kaufman, D W et al. (1997) Aplastic anemia in rural Thailand: its association with grain farming and agricultural pesticide exposure. Aplastic Anemia Study Group. Am J Public Health 87:1551-4
Issaragrisil, S; Kaufman, D W; Anderson, T et al. (1997) Low drug attributability of aplastic anemia in Thailand. The Aplastic Anemia Study Group. Blood 89:4034-9

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