Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL035252-04
Application #
3348963
Study Section
Cardiovascular and Renal Study Section (CVB)
Project Start
1986-12-01
Project End
1990-08-31
Budget Start
1989-12-01
Budget End
1990-08-31
Support Year
4
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Brigham and Women's Hospital
Department
Type
DUNS #
071723621
City
Boston
State
MA
Country
United States
Zip Code
02115
Tomita, Naruya; Kim, John Y S; Gibbons, Gary H et al. (2004) Gene therapy with an E2F transcription factor decoy inhibits cell cycle progression in rat anti-Thy 1 glomerulonephritis. Int J Mol Med 13:629-36
Akishita, M; Shirakami, G; Iwai, M et al. (2001) Angiotensin converting enzyme inhibitor restrains inflammation-induced vascular injury in mice. J Hypertens 19:1083-8
Daviet, L; Lehtonen, J Y; Hayashida, W et al. (2001) Intracellular third loops in AT1 and AT2 receptors determine subtype specificity. Life Sci 69:509-16
Tomita, N; Morishita, R; Tomita, S et al. (2000) Transcription factor decoy for NFkappaB inhibits TNF-alpha-induced cytokine and adhesion molecule expression in vivo. Gene Ther 7:1326-32
Horiuchi, M; Hayashida, W; Akishita, M et al. (2000) Interferon-gamma induces AT(2) receptor expression in fibroblasts by Jak/STAT pathway and interferon regulatory factor-1. Circ Res 86:233-40
Akishita, M; Iwai, M; Wu, L et al. (2000) Inhibitory effect of angiotensin II type 2 receptor on coronary arterial remodeling after aortic banding in mice. Circulation 102:1684-9
Horiuchi, M; Hayashida, W; Akishita, M et al. (1999) Stimulation of different subtypes of angiotensin II receptors, AT1 and AT2 receptors, regulates STAT activation by negative crosstalk. Circ Res 84:876-82
Daviet, L; Lehtonen, J Y; Tamura, K et al. (1999) Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor. J Biol Chem 274:17058-62
Horiuchi, M; Yamada, H; Akishita, M et al. (1999) Interferon regulatory factors regulate interleukin-1beta-converting enzyme expression and apoptosis in vascular smooth muscle cells. Hypertension 33:162-6
Tomita, S; Tomita, N; Yamada, T et al. (1999) Transcription factor decoy to study the molecular mechanism of negative regulation of renin gene expression in the liver in vivo. Circ Res 84:1059-66

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