Classically, the heart is viewed as consisting of two pumps in series, with the output of one ventricle becoming the input to the other ventricle. Thus, one ventricle could only influence the other ventricle by changing its output, thereby, eventually changing the input to the other ventricle. However, the anatomical association between the ventricles suggest that a direct myocardial relationship exists. Changes in the volume of one ventricle have been shown to effect the diastolic compliance and shape of the contralateral ventricle. In isolated heart preparations, changes in left ventricular volume and free wall integrity have shown to alter right ventricular systolic pressure. Recent experimental studied have shown changes in left ventricular filling charactristics caused by acute changes in right ventricular volume. Experimental and clinical data suggest that ventricular interactions are also important in the pathophysiology of pressure overload and volume overload. This study will examine biventricular mechanics in the intact dog by simultaneous measurements of left and right ventricular pressures and volumes. A computer algorithm will use the positional information obtained from radiopaque markers implanted on the ventricular endocardial surface to calculate the ventricular volumes. Using this preparation, the effects of chronic ventricular hypertrophy on ventricular interdependence will be examined. The information obtained in this study will provide new insight into ventricular mechanics in normal and pathological conditions, and will improve the understanding of the mechanisms which produce right ventricular dysfunction.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
7R01HL036068-01
Application #
3350654
Study Section
Cardiovascular Study Section (CVA)
Project Start
1985-08-01
Project End
1987-07-31
Budget Start
1985-08-01
Budget End
1986-07-31
Support Year
1
Fiscal Year
1985
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
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George, D T; DiLoreto, G V; Cheng, W et al. (1992) Voltage-dependent performance of skeletal muscle pouches: implications for cardiomyoplasty. J Heart Lung Transplant 11:S320-7
Santamore, W P; Burkhoff, D (1991) Hemodynamic consequences of ventricular interaction as assessed by model analysis. Am J Physiol 260:H146-57

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