Social class differences in mortality and morbidity from a wide range of diseases persist in the USA, UK and other industrialised countries. We wish to determine the extent to which psychosocial factors at work and outside account for these social class differences. The overall aim is to study: a) the effect on health and disease of the work environment - psychological workload, control over work pacing and content, opportunity for use of skills, social support at work, b) the moderating effect on these relationships of social supports, and c) the interaction between these psychosocial factors and other established risk factors in the aetiology of chronic disease. Our previous studies in the British Civil Service demonstrated a threefold higher mortality from cardiovascular and non-cardiovascular disease in the lowest compared to the highest employment grade. This difference could be explained only in part by differences in smoking, leisure-time physical activity, plasma choloesterol, blood pressure or obesity. We propose a new study, initially cross-sectional, of 11,000 civil servants, men and women aged 35-55, working in London. Assessments will be made by questionnaire and validated by interview of work characteristics, social supports, Type A behaviour pattern, stressful life circumstances. We shall quantify their relationship a) to health behaviours such as smoking, alcohol consumption and physical activity, b) to biological risk factors such as blood pressure and plasma cholesterol, c) to prevalence of cardiac and respiratory illness and d) to prevalence of neurotic disorder. We shall collect sickness absence data prospectively. In the longer term, using the sickness absence data and the National Health Service Central Death Registry, we shall examine the relationship of these psychosocial and other factors to morbidity and mortality from specific diseases. This study will take place alongside a randomised controlled trial of behaviour modification using biofeedback-aided relaxation aimed at reducing morbidity in the 1000 persons screened who are at highest risk of cardiovascular disease.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL036310-01
Application #
3351228
Study Section
Behavioral Medicine Study Section (BEM)
Project Start
1986-07-01
Project End
1989-06-30
Budget Start
1986-07-01
Budget End
1987-06-30
Support Year
1
Fiscal Year
1986
Total Cost
Indirect Cost
Name
University of London
Department
Type
DUNS #
City
London
State
Country
United Kingdom
Zip Code
Johnson, William; Bell, Joshua A; Robson, Ellie et al. (2018) Do worse baseline risk factors explain the association of healthy obesity with increased mortality risk? Whitehall II Study. Int J Obes (Lond) :
Welch, Catherine A; Sabia, Séverine; Brunner, Eric et al. (2018) Does pattern mixture modelling reduce bias due to informative attrition compared to fitting a mixed effects model to the available cases or data imputed using multiple imputation?: a simulation study. BMC Med Res Methodol 18:89
Tynkkynen, Juho; Chouraki, Vincent; van der Lee, Sven J et al. (2018) Association of branched-chain amino acids and other circulating metabolites with risk of incident dementia and Alzheimer's disease: A prospective study in eight cohorts. Alzheimers Dement 14:723-733
Mortensen, Jesper; Dich, Nadya; Lange, Theis et al. (2018) Weekly hours of informal caregiving and paid work, and the risk of cardiovascular disease. Eur J Public Health 28:743-747
Akbaraly, Tasnime; Würtz, Peter; Singh-Manoux, Archana et al. (2018) Association of circulating metabolites with healthy diet and risk of cardiovascular disease: analysis of two cohort studies. Sci Rep 8:8620
O'Neill, Dara; Britton, Annie; Hannah, Mary K et al. (2018) Association of longitudinal alcohol consumption trajectories with coronary heart disease: a meta-analysis of six cohort studies using individual participant data. BMC Med 16:124
Mein, Gill; Grant, Robert (2018) A cross-sectional exploratory analysis between pet ownership, sleep, exercise, health and neighbourhood perceptions: the Whitehall II cohort study. BMC Geriatr 18:176
Fleischmann, Maria; Carr, Ewan; Stansfeld, Stephen A et al. (2018) Can favourable psychosocial working conditions in midlife moderate the risk of work exit for chronically ill workers? A 20-year follow-up of the Whitehall II study. Occup Environ Med 75:183-190
Akbaraly, Tasnime; Sexton, Claire; Zsoldos, Enik? et al. (2018) Association of Long-Term Diet Quality with Hippocampal Volume: Longitudinal Cohort Study. Am J Med 131:1372-1381.e4
Carr, Ewan; Fleischmann, Maria; Goldberg, Marcel et al. (2018) Occupational and educational inequalities in exit from employment at older ages: evidence from seven prospective cohorts. Occup Environ Med 75:369-377

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