Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL036574-02
Application #
3351648
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1987-05-01
Project End
1990-04-30
Budget Start
1988-05-01
Budget End
1989-04-30
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Webb, C L; Schoen, F J; Flowers, W E et al. (1991) Inhibition of mineralization of glutaraldehyde-pretreated bovine pericardium by AlCl3. Mechanisms and comparisons with FeCl3, LaCl3, and Ga(NO3)3 in rat subdermal model studies. Am J Pathol 138:971-81
Webb, C L; Schoen, F J; Levy, R J (1989) Covalent binding of aminopropanehydroxydiphosphonate to glutaraldehyde residues in pericardial bioprosthetic tissue: stability and calcification inhibition studies. Exp Mol Pathol 50:291-302
Webb, C L; Benedict, J J; Schoen, F J et al. (1988) Inhibition of bioprosthetic heart valve calcification with aminodiphosphonate covalently bound to residual aldehyde groups. Ann Thorac Surg 46:309-16
Maranto, A R; Schoen, F J (1988) Phosphatase enzyme activity is retained in glutaraldehyde treated bioprosthetic heart valves. ASAIO Trans 34:827-30
Webb, C L; Schoen, F J; Levy, R J (1988) AL preincubation inhibits calcification of bioprosthetic heart valve tissue in the rat subdermal model. ASAIO Trans 34:855-9
Webb, C L; Phelps, L L; Schoen, F J et al. (1988) Aminodiphosphonate or AI preincubation inhibits calcification of aortic homografts in the rat subdermal model. ASAIO Trans 34:851-4
Schoen, F J; Harasaki, H; Kim, K M et al. (1988) Biomaterial-associated calcification: pathology, mechanisms, and strategies for prevention. J Biomed Mater Res 22:11-36
Maranto, A R; Schoen, F J (1988) Effect of delay between tissue harvest and glutaraldehyde pretreatment on mineralization of bovine pericardium used in bioprosthetic heart valves. J Biomed Mater Res 22:819-25
Schoen, F J; Kujovich, J L; Webb, C L et al. (1987) Chemically determined mineral content of explanted porcine aortic valve bioprostheses: correlation with radiographic assessment of calcification and clinical data. Circulation 76:1061-6