Cellular Mechanism of Nitrofurantoin Lung Toxicity

Martin, William J.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 5R01HL036778-02
• Application #: 3352023
• Study Section: Toxicology Study Section (TOX)
• Project Start: 1987-04-01
• Project End: 1988-06-30
• Budget Start: 1988-04-01
• Budget End: 1988-06-30
• Support Year: 2
• Fiscal Year: 1988

Institution

• Name: Mayo Clinic, Rochester
• City: Rochester
• State: MN
• Country: United States
• Zip Code: 55905

Publications

Martin 2nd, W J; Kachel, D L (1989) Oxygen-mediated impairment of human pulmonary endothelial cell growth: evidence for a specific threshold of toxicity. J Lab Clin Med 113:413-21

Oakes, S G; Martin 2nd, W J; Lisek, C A et al. (1988) Incomplete hydrolysis of the calcium indicator precursor fura-2 pentaacetoxymethyl ester (fura-2 AM) by cells. Anal Biochem 169:159-66

Lyng, P J; Kachel, D L; Martin 2nd, W J (1988) Importance of hydrogen peroxide in nitrofurantoin-induced cytotoxicity: evidence from an inbred catalase-deficient strain of mice. J Lab Clin Med 112:301-6

Martin 2nd, W J; Kachel, D L (1987) Bleomycin-induced pulmonary endothelial cell injury: evidence for the role of iron-catalyzed toxic oxygen-derived species. J Lab Clin Med 110:153-8