Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL037250-09
Application #
2218393
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1986-12-01
Project End
1998-03-31
Budget Start
1995-04-01
Budget End
1998-03-31
Support Year
9
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Suny Downstate Medical Center
Department
Biochemistry
Type
Schools of Medicine
DUNS #
068552207
City
Brooklyn
State
NY
Country
United States
Zip Code
11203
Essex, D W; Miller, A; Swiatkowska, M et al. (1999) Protein disulfide isomerase catalyzes the formation of disulfide-linked complexes of vitronectin with thrombin-antithrombin. Biochemistry 38:10398-405
Milev, Y; Essex, D W (1999) Protein disulfide isomerase catalyzes the formation of disulfide-linked complexes of thrombospondin-1 with thrombin-antithrombin III. Arch Biochem Biophys 361:120-6
Huang, E M; Detwiler, T C; Milev, Y et al. (1997) Thiol-disulfide isomerization in thrombospondin: effects of conformation and protein disulfide isomerase. Blood 89:3205-12
Chen, K; Detwiler, T C; Essex, D W (1995) Characterization of protein disulphide isomerase released from activated platelets. Br J Haematol 90:425-31
Essex, D W; Chen, K; Swiatkowska, M (1995) Localization of protein disulfide isomerase to the external surface of the platelet plasma membrane. Blood 86:2168-73
Chen, K; Essex, D W (1995) Purification of secreted platelet protease nexin I. Thromb Res 79:527-9
Chang, A C; Detwiler, T C (1992) Reactions of thrombin-serpin complexes with thrombospondin. Arch Biochem Biophys 299:100-4
Chen, K; Lin, Y; Detwiler, T C (1992) Protein disulfide isomerase activity is released by activated platelets. Blood 79:2226-8
Chang, A C; Detwiler, T C (1991) The reaction of thrombin with platelet-derived nexin requires a secondary recognition site in addition to the catalytic site. Biochem Biophys Res Commun 177:1198-204
Speziale, M V; Detwiler, T C (1991) Reduction of a disulfide bond of thrombospondin in the supernatant solution of activated platelets. Arch Biochem Biophys 286:546-50

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