The objective of the research is to develop and evaluate an oxygen-consumption meter (metabolic monitor), capable of breath-by-breath response. The stand-alone instrument is designed for use in anesthesia monitoring and features a small transducer assembly of unique design that is inserted between the tracheal tube and the anesthesia machine. The transducer assembly contains a low-resistance disposable and sterilizable pneumotachograph of a new design and a rapidly responding oxygen-concentration detector, also of a new design, operating on the principle of ultraviolet absorption. The oxygen uptake per breath is the volume per breath (measured with the pneumotachograph) multiplied by the difference in inspired and expired oxygen concentration. The metabolic monitor will indicate heart rate, respiratory rate, tidal volume and minute volume, as well as the oxygen uptake per breath and per minute, which is the minute sum of the uptakes per breath. The metabolic monitor will be evaluated on experimental animals under a variety of anesthesia conditions. Selected trials will also be made on human subjects under gaseous anesthesia.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL037345-02
Application #
3352916
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1987-02-04
Project End
1990-01-31
Budget Start
1988-02-01
Budget End
1989-01-31
Support Year
2
Fiscal Year
1988
Total Cost
Indirect Cost
Name
Purdue University
Department
Type
DUNS #
072051394
City
West Lafayette
State
IN
Country
United States
Zip Code
47907
de las Alas, V; Voorhees, W D; Geddes, L A et al. (1990) End-tidal carbon dioxide concentration, carbon dioxide production, heart rate, and blood pressure as indicators of induced hyperthermia. J Clin Monit 6:183-5
Delas Alas, V; Geddes, L A; Voorhees, W D et al. (1990) End-tidal CO2, CO2 production, and O2 consumption as early indicators of approaching hyperthermia. Biomed Instrum Technol 24:440-4