Ischemia and Hypoxia in the Neonatal Heart

Downing, Shirley E.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 5R01HL038034-02
• Application #: 3354022
• Study Section: Cardiovascular Study Section (CVA)
• Project Start: 1987-05-01
• Project End: 1992-04-30
• Budget Start: 1988-05-01
• Budget End: 1989-04-30
• Support Year: 2
• Fiscal Year: 1988

Institution

• Name: Yale University
• Type: Schools of Medicine
• DUNS #: 082359691
• City: New Haven
• State: CT
• Country: United States
• Zip Code: 06520

Publications

Offstad, J; Kirkeboen, K A; Ilebekk, A et al. (1994) ATP gated potassium channels in acute myocardial hibernation and reperfusion. Cardiovasc Res 28:872-80

Downing, S E (1993) Wall tension and myocardial dysfunction after ischemia and reperfusion. Am J Physiol 264:H386-93

McGowan Jr, F X; Lee, F A; Chen, V et al. (1992) Oxidative metabolism and mechanical function in reperfused neonatal pig heart. J Mol Cell Cardiol 24:831-40

Downing, S E; Chen, V (1992) Effects of catecholamine stimulation on myocardial hibernation. Am Heart J 123:589-96

Downing, S E; Chen, V (1992) Acute hibernation and reperfusion of the ischemic heart. Circulation 85:699-707

Jiang, J P; Chen, V; Downing, S E (1991) Modulation of catecholamine cardiomyopathy by allopurinol. Am Heart J 122:115-21

Chen, V; Downing, S E (1990) Preservation of cardiac metabolic capacity after acute catecholamine injury. Am J Physiol 258:H101-6

Jiang, J P; Downing, S E (1990) Catecholamine cardiomyopathy: review and analysis of pathogenetic mechanisms. Yale J Biol Med 63:581-91

Downing, S E; Chen, V (1990) Myocardial hibernation in the ischemic neonatal heart. Circ Res 66:763-72

Ascuitto, R J; Ross-Ascuitto, N T; Chen, V et al. (1989) Ventricular function and fatty acid metabolism in neonatal piglet heart. Am J Physiol 256:H9-15