Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL038245-02S1
Application #
3354374
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1990-09-01
Project End
1994-06-30
Budget Start
1990-09-01
Budget End
1991-06-30
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Duke University
Department
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705
Lai, T S; Hausladen, A; Slaughter, T F et al. (2001) Calcium regulates S-nitrosylation, denitrosylation, and activity of tissue transglutaminase. Biochemistry 40:4904-10
Blackwell, K L; Haroon, Z A; Shan, S et al. (2000) Tamoxifen inhibits angiogenesis in estrogen receptor-negative animal models. Clin Cancer Res 6:4359-64
Haroon, Z A; Raleigh, J A; Greenberg, C S et al. (2000) Early wound healing exhibits cytokine surge without evidence of hypoxia. Ann Surg 231:137-47
Haroon, Z A; Lai, T S; Hettasch, J M et al. (1999) Tissue transglutaminase is expressed as a host response to tumor invasion and inhibits tumor growth. Lab Invest 79:1679-86
Haroon, Z A; Hettasch, J M; Lai, T S et al. (1999) Tissue transglutaminase is expressed, active, and directly involved in rat dermal wound healing and angiogenesis. FASEB J 13:1787-95
Lai, T S; Slaughter, T F; Peoples, K A et al. (1998) Regulation of human tissue transglutaminase function by magnesium-nucleotide complexes. Identification of distinct binding sites for Mg-GTP and Mg-ATP. J Biol Chem 273:1776-81
Hettasch, J M; Peoples, K A; Greenberg, C S (1997) Analysis of factor XIII substrate specificity using recombinant human factor XIII and tissue transglutaminase chimeras. J Biol Chem 272:25149-56
Lai, T S; Bielawska, A; Peoples, K A et al. (1997) Sphingosylphosphocholine reduces the calcium ion requirement for activating tissue transglutaminase. J Biol Chem 272:16295-300
Lai, T S; Slaughter, T F; Koropchak, C M et al. (1996) C-terminal deletion of human tissue transglutaminase enhances magnesium-dependent GTP/ATPase activity. J Biol Chem 271:31191-5
Lai, T S; Achyuthan, K E; Santiago, M A et al. (1994) Carboxyl-terminal truncation of recombinant factor XIII A-chains. Characterization of minimum structural requirement for transglutaminase activity. J Biol Chem 269:24596-601

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