The structure of the TM gene and the structure function relationships of the TM receptor will be defined. The structure of the promoter/enhancer subdomains of the TM gene will be elucidated. Specific transacting factors which regulate TM gene expression will be delineated and purified. The pathbioology of TM gene expression will be examined.
| Conway, E M; Bach, R; Rosenberg, R D et al. (1989) Tumor necrosis factor enhances expression of tissue factor mRNA in endothelial cells. Thromb Res 53:231-41 |
| Conway, E M; Rosenberg, R D (1988) Tumor necrosis factor suppresses transcription of the thrombomodulin gene in endothelial cells. Mol Cell Biol 8:5588-92 |
| Jackman, R W; Beeler, D L; Fritze, L et al. (1987) Human thrombomodulin gene is intron depleted: nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control. Proc Natl Acad Sci U S A 84:6425-9 |
