The overall goal of the research is to define, through cross-sectional and longitudinal analyses, the role of nutritional and dietary variables in determining atherogenic traits and the morbidity and mortality due to coronary heart disease observed in the Framingham heart Study Cohort and Offspring/Spouse Populations. The associations between nutritional variables and major atherogenic risk factors (dyslipidemia, elevated blood pressure, impaired glucose tolerance and overweight) will be investigated cross-sectionally in the total Offspring/Spouse population. The independent, quantitative effects of dietary factors on the prediction of cardiovascular morbidity and mortality will be explored longitudinally in two samples of the original Framingham Cohort at 20 and 30 years of followup (n = 859 (males) and 912 (men and women), respectively). Six major steps will be followed in each set of analyses: dimension reduction using cluster and factor analysis; zero order independent nutrition variable analyses (multiple regression); stepwise multiple regression of independent variables; specification of overall regression models; stability and validity testing; and the addition of intervening variables using multiple regression techniques. We will also conduct multivariate analyses of the dependent variables to determine associations and interactions among these variables. The proposed analyses should indicate: 1) how nutrition variables or clusters contribute to the longitudinal development of heart disease morbidity and mortality in the Framingham Cohort at 20 and 30 years of followup: and 2) how nutrition variables and clusters relate to atherogenic traits on cross-sectional analysis of the Offspring/Spouses.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL039144-02
Application #
3355765
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Project Start
1989-08-01
Project End
1992-07-31
Budget Start
1990-08-01
Budget End
1991-07-31
Support Year
2
Fiscal Year
1990
Total Cost
Indirect Cost
Name
Boston University
Department
Type
Schools of Allied Health Profes
DUNS #
604483045
City
Boston
State
MA
Country
United States
Zip Code
02118
Millen, B E; Quatromoni, P A; Gagnon, D R et al. (1996) Dietary patterns of men and women suggest targets for health promotion: the Framingham Nutrition Studies. Am J Health Promot 11:42-52;discussion 52-3
Posner, B M; Franz, M M; Quatromoni, P A et al. (1995) Secular trends in diet and risk factors for cardiovascular disease: the Framingham Study. J Am Diet Assoc 95:171-9
Howland, J; Peterson, E W; Levin, W C et al. (1993) Fear of falling among the community-dwelling elderly. J Aging Health 5:229-43
Campos, H; Willett, W C; Peterson, R M et al. (1991) Nutrient intake comparisons between Framingham and rural and Urban Puriscal, Costa Rica. Associations with lipoproteins, apolipoproteins, and low density lipoprotein particle size. Arterioscler Thromb 11:1089-99