Sympathetic neural and humoral stimuli influence coronary vascular resistance directly through effects on coronary vessels and indirectly through effects on the myocardium. Although animal studies suggest that the indirect dilator effects of sympathetic stimulation usually overshadow direct constrictor effects, recent work has shown that direct effects can play a dominant role in control of coronary vascular resistance. Information on neural control of coronary vascular resistance in humans is limited and has been difficult to obtain primarily for methodological reasons. We have recently developed and validated a small intralumenal Doppler catheter which can measure phasic coronary blood flow velocity in conscious humans. We will utilize this catheter to study coronary blood flow velocity in response to reflex and direct sympathetic stimuli asking three questions: 1) Is the neurogenic constrictor response accentuated in the presence of hypercholesterolemia without significant coronary lesions? 2) Is this response accentuated in the presence of coronary atherosclerosis? 3) Does beta blockade unmask accentuated adrenergic coronary vasoconstriction in patients with coronary lesions? Using the coronary blood flow velocity response to intracoronary papaverine as a measure of selective vasodilator reserve and quantitative coronary angiography to assess lesion geometry, we will study vasodilator reserve, lesion geometry, and neural control of coronary blood flow velocity in normals and patients with coronary atherosclerosis. This methodology should allow us to obtain fundamental new insights into neural regulation of the coronary circulation in humans.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL039185-01
Application #
3355845
Study Section
Cardiovascular Study Section (CVA)
Project Start
1987-04-01
Project End
1990-03-31
Budget Start
1987-04-01
Budget End
1988-03-31
Support Year
1
Fiscal Year
1987
Total Cost
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Type
Schools of Medicine
DUNS #
168559177
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Wilson, R F; Christensen, B V; Olivari, M T et al. (1991) Evidence for structural sympathetic reinnervation after orthotopic cardiac transplantation in humans. Circulation 83:1210-20
Wilson, R F; Laxson, D D; Lesser, J R et al. (1989) Intense microvascular constriction after angioplasty of acute thrombotic coronary arterial lesions. Lancet 1:807-11
McGinn, A L; Wilson, R F; Olivari, M T et al. (1988) Coronary vasodilator reserve after human orthotopic cardiac transplantation. Circulation 78:1200-9
Wilson, R F; White, C W (1988) Serious ventricular dysrhythmias after intracoronary papaverine. Am J Cardiol 62:1301-2