Cigarette Smoking has been decribed as the most significant preventable cause of premature death and disability in industrialized countries. Smoking is a proven risk factor for the three leading causes of death in the United States: heart disease, malignant neoplasms, and stroke. It is estimated that smoking is causally related to some 225,000 deaths due to cardiovascular disease, 80,000 deaths from lung cancer, 22,000 deaths from other cancers, and more than 19,000 deaths from pulmonary disease annually in the U.S. alone. Although considerable media attention has been devoted to the health consequences of smoking (U.S.P.H.S., 1982), appoximately one-third of adults continue to smoke. While posttreatment cessation rates have risen somewhat over the past decade, up to 80% of smokers who initially stop smoking will relapse within a very short period of time. One neglected variable in the smoking relapse area is weight gain following smoking cessation. Recent surveys indicate that 1/3 of all smokers (39% of female smokers and 25% of male smokers) report that they smoke in order to regulate their body weight. Despite the obvious relationship between smoking and weight gain, very little is known regarding the reasons for weight gain following smoking cessation. There is recent evidence that the predictors of weight gain may be different in men than in women. Thus, the goals of this project are threefold. First, we intend to determine, in a comprehensive fashion, the determinants (i.e., food intake, physical activity, changes in metabolic rate) of weight gain following smoking cessation in a biracial sample of 800 adult males and females. Our second goal is to determine who (i.e., Blacks vs Whites; males vs females) is most at risk for potential weight gain and relapse. Our final goal is to determine if weight gain following smoking cessation predicts relapse in a prospective, multiple assessment design. The outcomes of this research will have extremely important implications for future intervention efforts.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL039332-04
Application #
3356155
Study Section
Behavioral Medicine Study Section (BEM)
Project Start
1988-06-01
Project End
1993-05-31
Budget Start
1991-06-01
Budget End
1993-05-31
Support Year
4
Fiscal Year
1991
Total Cost
Indirect Cost
Name
University of Memphis
Department
Type
Schools of Arts and Sciences
DUNS #
City
Memphis
State
TN
Country
United States
Zip Code
38152
Winders, S E; Grunberg, N E; Benowitz, N L et al. (1998) Effects of stress on circulating nicotine and cotinine levels and in vitro nicotine metabolism in the rat. Psychopharmacology (Berl) 137:383-90
Meyers, A W; Klesges, R C; Winders, S E et al. (1997) Are weight concerns predictive of smoking cessation? A prospective analysis. J Consult Clin Psychol 65:448-52
Eck, L H; Bennett, A G; Egan, B M et al. (1997) Differences in macronutrient selections in users and nonusers of an oral contraceptive. Am J Clin Nutr 65:419-24
Klesges, R C; Winders, S E; Meyers, A W et al. (1997) How much weight gain occurs following smoking cessation? A comparison of weight gain using both continuous and point prevalence abstinence. J Consult Clin Psychol 65:286-91
Eck, L H; Klesges, L M; Klesges, R C (1996) Precision and estimated accuracy of two short-term food frequency questionnaires compared with recalls and records. J Clin Epidemiol 49:1195-200
Klesges, R C; Eck, L H; Ray, J W (1995) Who underreports dietary intake in a dietary recall? Evidence from the Second National Health and Nutrition Examination Survey. J Consult Clin Psychol 63:438-44
Winders, S E; Amos, J C; Wilson, M R et al. (1994) Effects of chronic phenylpropanolamine infusion and termination on body weight, food consumption and water consumption in rats. Psychopharmacology (Berl) 114:513-9
Eck, L H; Ray, J W; Klesges, R C et al. (1994) Physicians' diagnosis of obesity status in NHANES II. Int J Obes Relat Metab Disord 18:704-8
Camp, D E; Klesges, R C; Relyea, G (1993) The relationship between body weight concerns and adolescent smoking. Health Psychol 12:24-32
Winders, S E; Wilkins 2nd, D R; Rushing, P A et al. (1993) Effects of nicotine cycling on weight loss and regain in male rats. Pharmacol Biochem Behav 46:209-13

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