application) This is a proposal to improve the utility of 2-D ultrasound imaging for use in clinical trials and cardiovascular epidemiology. The investigators will acquire B-mode images with commercially available ultrasound scanning equipment augmented with a spatial locator device. Computer software will be developed to combine multiple B-mode images into a three-dimensional ultrasound image of the deep wall of the vessel. The lumen and media/adventitia boundaries will be located in the composite image and a three dimensional map of wall thickness generated. From this map, areas of wall thickening will be localized and atherosclerosis measures such as size and distribution of discrete lesions and the extent of wall thickening above a specified threshold will be computed. Accuracy of lesion assessment will be estimated from phantom studies and overall precision of the method from repeat human scans. Twenty individuals participating in an on-going clinical atherosclerosis regression trial will receive ultrasound scans with a commercially available instrument at six month intervals for a period of 24 months and the computer method will be used to determine changes in wall thickness and lesion size.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL040098-01A2
Application #
3357183
Study Section
Diagnostic Radiology Study Section (RNM)
Project Start
1990-04-01
Project End
1993-03-31
Budget Start
1990-04-01
Budget End
1991-03-31
Support Year
1
Fiscal Year
1990
Total Cost
Indirect Cost
Name
California Institute of Technology
Department
Type
Organized Research Units
DUNS #
078731668
City
Pasadena
State
CA
Country
United States
Zip Code
91125