The primary function of blood flow through the lungs is gas exchange. Therefore, it would be advantageous if this function was performed with the optimal use of energy costs. Under normal conditions the hemodynamic properties of the pulmonary circulation and the heart appear to be matched to maximize right ventricular hydraulic power output. This matching depends not only on input resistance, but also on characteristic impedance and pulmonary arterial compliance. The purpose of this study is to determine the changes of hemodynamic properties during acute circulatory disturbances and the mechanisms involved. It is planned to estimate the characteristic impedance and compliance of the main pulmonary artery from measurements of pressure and diameter in both awake and anesthetized dogs. Flow will be calculated from the measurement of blood velocity and vascular dimensions and used to estimate pulmonary arterial input impedance. In awake preparations, it is proposed to determine the uniformity of the mechanical properties of the main pulmonary artery and the role of the autonomic nervous system in controlling the mechanical properties of the main pulmonary artery under resting conditions. In anesthetized preparations, it is proposed to measure pressure-diameter relations of the main pulmonary artery in response to acute circulatory disturbances: (1) alterations of cardiac output, (2) pulmonary vascular obstruction and (3) increases of left atrial pressure. The results of these experiments will be used to determine if the pulmonary hemodynamic variables change in a manner that could be explained by passive mechanical effects. The measurements of vascular dimensions and pressure will enable the relative contributions of geometry and elasticity on vascular compliance to be determined. The role of active mechanisms mediated through the autonomic nervous system will be investigated by the use of blocking agents.
| Li, Z; Grant, B J; Lieber, B B (1995) Time-varying pulmonary arterial input impedance via wavelet decomposition. J Appl Physiol 78:2309-19 |
| Magalang, U J; Grant, B J (1995) Determination of gas exchange threshold by nonparametric regression. Am J Respir Crit Care Med 151:98-106 |
| Klocke, R A; Schunemann, H J; Grant, B J (1995) Distribution of pulmonary capillary transit times. Am J Respir Crit Care Med 152:2014-20 |
| Lieber, B B; Li, Z; Grant, B J (1994) Beat-by-beat changes of viscoelastic and inertial properties of the pulmonary arteries. J Appl Physiol 76:2348-55 |
| Grant, B J (1994) Noninvasive tests for acute venous thromboembolism. Am J Respir Crit Care Med 149:1044-7 |
| Grant, B J; Canty Jr, J M; Srinivasan, G et al. (1993) Pulmonary arterial elasticity in awake dogs. J Appl Physiol 75:840-8 |
| Grant, B J; Lieber, B B (1992) Compliance of the main pulmonary artery during the ventilatory cycle. J Appl Physiol 72:535-42 |
| Grant, B J; Fitzpatrick, J M; Lieber, B B (1991) Time-varying pulmonary arterial compliance. J Appl Physiol 70:575-83 |
| Grant, B J; Sherif, S M (1991) Flow-mediated vasodilatation of the main pulmonary artery. Respir Physiol 86:77-90 |
| Fitzpatrick, J M; Grant, B J (1990) Effects of pulmonary vascular obstruction on right ventricular afterload. Am Rev Respir Dis 141:944-52 |
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