Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL041212-07
Application #
2219934
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1988-12-01
Project End
1997-05-31
Budget Start
1994-12-01
Budget End
1997-05-31
Support Year
7
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Fred Hutchinson Cancer Research Center
Department
Type
DUNS #
075524595
City
Seattle
State
WA
Country
United States
Zip Code
98109
Koeberl, D D; Alexander, I E; Halbert, C L et al. (1997) Persistent expression of human clotting factor IX from mouse liver after intravenous injection of adeno-associated virus vectors. Proc Natl Acad Sci U S A 94:1426-31
Adam, M A; Osborne, W R; Miller, A D (1995) R-region cDNA inserts in retroviral vectors are compatible with virus replication and high-level protein synthesis from the insert. Hum Gene Ther 6:1169-76
Koeberl, D D; Halbert, C L; Krumm, A et al. (1995) Sequences within the coding regions of clotting factor VIII and CFTR block transcriptional elongation. Hum Gene Ther 6:469-79
Russell, D W; Miller, A D; Alexander, I E (1994) Adeno-associated virus vectors preferentially transduce cells in S phase. Proc Natl Acad Sci U S A 91:8915-9
Alexander, I E; Russell, D W; Miller, A D (1994) DNA-damaging agents greatly increase the transduction of nondividing cells by adeno-associated virus vectors. J Virol 68:8282-7
Lynch, C M; Israel, D I; Kaufman, R J et al. (1993) Sequences in the coding region of clotting factor VIII act as dominant inhibitors of RNA accumulation and protein production. Hum Gene Ther 4:259-72
Palmer, T D; Miller, A D; Reeder, R H et al. (1993) Efficient expression of a protein coding gene under the control of an RNA polymerase I promoter. Nucleic Acids Res 21:3451-7
Palmer, T D; Rosman, G J; Osborne, W R et al. (1991) Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes. Proc Natl Acad Sci U S A 88:1330-4
Kaleko, M; Garcia, J V; Miller, A D (1991) Persistent gene expression after retroviral gene transfer into liver cells in vivo. Hum Gene Ther 2:27-32
Adam, M A; Ramesh, N; Miller, A D et al. (1991) Internal initiation of translation in retroviral vectors carrying picornavirus 5' nontranslated regions. J Virol 65:4985-90

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