Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL041776-06A2
Application #
2220141
Study Section
Biochemistry Study Section (BIO)
Project Start
1988-12-01
Project End
2001-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Eastern Virginia Medical School
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Norfolk
State
VA
Country
United States
Zip Code
23501
Heeley, David H; Belknap, Betty; White, Howard D (2006) Maximal activation of skeletal muscle thin filaments requires both rigor myosin S1 and calcium. J Biol Chem 281:668-76
Heeley, David H; Belknap, Betty; White, Howard D (2002) Mechanism of regulation of phosphate dissociation from actomyosin-ADP-Pi by thin filament proteins. Proc Natl Acad Sci U S A 99:16731-6
Ikebe, R; Reardon, S; Mitsui, T et al. (1999) Role of the N-terminal region of the regulatory light chain in the dephosphorylation of myosin by myosin light chain phosphatase. J Biol Chem 274:30122-6
Kambara, T; Rhodes, T E; Ikebe, R et al. (1999) Functional significance of the conserved residues in the flexible hinge region of the myosin motor domain. J Biol Chem 274:16400-6
White, H D; Belknap, B; Webb, M R (1997) Kinetics of nucleoside triphosphate cleavage and phosphate release steps by associated rabbit skeletal actomyosin, measured using a novel fluorescent probe for phosphate. Biochemistry 36:11828-36
Persechini, A; White, H D; Gansz, K J (1996) Different mechanisms for Ca2+ dissociation from complexes of calmodulin with nitric oxide synthase or myosin light chain kinase. J Biol Chem 271:62-7
Walker, M; Trinick, J; White, H (1995) Millisecond time resolution electron cryo-microscopy of the M-ATP transient kinetic state of the acto-myosin ATPase. Biophys J 68:87S-91S
Walker, M; White, H; Belknap, B et al. (1994) Electron cryomicroscopy of acto-myosin-S1 during steady-state ATP hydrolysis. Biophys J 66:1563-72
Cooke, R; White, H; Pate, E (1994) A model of the release of myosin heads from actin in rapidly contracting muscle fibers. Biophys J 66:778-88
Pate, E; Franks-Skiba, K; White, H et al. (1993) The use of differing nucleotides to investigate cross-bridge kinetics. J Biol Chem 268:10046-53

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