Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL042886-08
Application #
2220735
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1990-09-01
Project End
1998-08-31
Budget Start
1996-09-01
Budget End
1998-08-31
Support Year
8
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of Texas Health Science Center Houston
Department
Pathology
Type
Schools of Medicine
DUNS #
City
Houston
State
TX
Country
United States
Zip Code
77225

  Publications

Gu, Yingqi; Zhou, Z Hong; McCarthy, Diane B et al. (2003) 3D electron microscopy reveals the variable deposition and protein dynamics of the peripheral pyruvate dehydrogenase component about the core. Proc Natl Acad Sci U S A 100:7015-20
Kong, Yifei; Ming, Dengming; Wu, Yinghao et al. (2003) Conformational flexibility of pyruvate dehydrogenase complexes: a computational analysis by quantized elastic deformational model. J Mol Biol 330:129-35
Kolodziej, Steven J; Wagenknecht, Terence; Strickland, Dudley K et al. (2002) The three-dimensional structure of the human alpha 2-macroglobulin dimer reveals its structural organization in the tetrameric native and chymotrypsin alpha 2-macroglobulin complexes. J Biol Chem 277:28031-7
Hudmon, A; Kim, S A; Kolb, S J et al. (2001) Light scattering and transmission electron microscopy studies reveal a mechanism for calcium/calmodulin-dependent protein kinase II self-association. J Neurochem 76:1364-75
Zhou, Z H; McCarthy, D B; O'Connor, C M et al. (2001) The remarkable structural and functional organization of the eukaryotic pyruvate dehydrogenase complexes. Proc Natl Acad Sci U S A 98:14802-7
Wu, L; Lo, P; Yu, X et al. (2000) Three-dimensional structure of the human herpesvirus 8 capsid. J Virol 74:9646-54
Qazi, U; Kolodziej, S J; Gettins, P G et al. (2000) The structure of the C949S mutant human alpha(2)-macroglobulin demonstrates the critical role of the internal thiol esters in its proteinase-entrapping structural transformation. J Struct Biol 131:19-26
Qazi, U; Gettins, P G; Strickland, D K et al. (1999) Structural details of proteinase entrapment by human alpha2-macroglobulin emerge from three-dimensional reconstructions of Fab labeled native, half-transformed, and transformed molecules. J Biol Chem 274:8137-42
Qazi, U; Gettins, P G; Stoops, J K (1998) On the structural changes of native human alpha2-macroglobulin upon proteinase entrapment. Three-dimensional structure of the half-transformed molecule. J Biol Chem 273:8987-93
Kolodziej, S J; Klueppelberg, H U; Nolasco, N et al. (1998) Three-dimensional structure of the human plasmin alpha2-macroglobulin complex. J Struct Biol 123:124-33

Showing the most recent 10 out of 17 publications