Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL043662-07
Application #
2221120
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1990-07-01
Project End
1998-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Parke Davis Pharmaceutical Research Div
Department
Type
DUNS #
City
Ann Arbor
State
MI
Country
United States
Zip Code
48105

  Publications

Liang, Q; Wiese, R J; Bueno, O F et al. (2001) The transcription factor GATA4 is activated by extracellular signal-regulated kinase 1- and 2-mediated phosphorylation of serine 105 in cardiomyocytes. Mol Cell Biol 21:7460-9
Liang, Q; De Windt, L J; Witt, S A et al. (2001) The transcription factors GATA4 and GATA6 regulate cardiomyocyte hypertrophy in vitro and in vivo. J Biol Chem 276:30245-53
Lee, Y; Shioi, T; Kasahara, H et al. (1998) The cardiac tissue-restricted homeobox protein Csx/Nkx2.5 physically associates with the zinc finger protein GATA4 and cooperatively activates atrial natriuretic factor gene expression. Mol Cell Biol 18:3120-9
Herzig, T C; Jobe, S M; Aoki, H et al. (1997) Angiotensin II type1a receptor gene expression in the heart: AP-1 and GATA-4 participate in the response to pressure overload. Proc Natl Acad Sci U S A 94:7543-8
Hasegawa, K; Lee, S J; Jobe, S M et al. (1997) cis-Acting sequences that mediate induction of beta-myosin heavy chain gene expression during left ventricular hypertrophy due to aortic constriction. Circulation 96:3943-53
Molkentin, J D; Jobe, S M; Markham, B E (1996) Alpha-myosin heavy chain gene regulation: delineation and characterization of the cardiac muscle-specific enhancer and muscle-specific promoter. J Mol Cell Cardiol 28:1211-25
Molkentin, J D; Kalvakolanu, D V; Markham, B E (1994) Transcription factor GATA-4 regulates cardiac muscle-specific expression of the alpha-myosin heavy-chain gene. Mol Cell Biol 14:4947-57
Molkentin, J D; Markham, B E (1994) An M-CAT binding factor and an RSRF-related A-rich binding factor positively regulate expression of the alpha-cardiac myosin heavy-chain gene in vivo. Mol Cell Biol 14:5056-65
Molkentin, J D; Brogan, R S; Jobe, S M et al. (1993) Expression of the alpha-myosin heavy chain gene in the heart is regulated in part by an E-box-dependent mechanism. J Biol Chem 268:2602-9
Molkentin, J D; Markham, B E (1993) Myocyte-specific enhancer-binding factor (MEF-2) regulates alpha-cardiac myosin heavy chain gene expression in vitro and in vivo. J Biol Chem 268:19512-20