Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL045916-06
Application #
2222542
Study Section
Biophysical Chemistry Study Section (BBCB)
Project Start
1991-01-01
Project End
2000-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of North Carolina Chapel Hill
Department
Biochemistry
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599

  Publications

Koklic, Tilen; Chattopadhyay, Rima; Majumder, Rinku et al. (2015) Factor Xa dimerization competes with prothrombinase complex formation on platelet-like membrane surfaces. Biochem J 467:37-46
Majumder, Rinku; Koklic, Tilen; Sengupta, Tanusree et al. (2014) Soluble phosphatidylserine binds to two sites on human factor IXa in a Ca2+ dependent fashion to specifically regulate structure and activity. PLoS One 9:e100006
Koklic, Tilen; Majumder, Rinku; Lentz, Barry R (2014) Ca2+ switches the effect of PS-containing membranes on Factor Xa from activating to inhibiting: implications for initiation of blood coagulation. Biochem J 462:591-601
Srivasatava, Kinshuk Raj; Majumder, Rinku; Kane, William H et al. (2014) Phosphatidylserine and FVa regulate FXa structure. Biochem J 459:229-39
Koklic, Tilen; Majumder, Rinku; Weinreb, Gabriel E et al. (2009) Factor XA binding to phosphatidylserine-containing membranes produces an inactive membrane-bound dimer. Biophys J 97:2232-41
Weinreb, Gabriel E; Mukhopadhyay, Kasturi; Majumder, Rinku et al. (2003) Cooperative roles of factor V(a) and phosphatidylserine-containing membranes as cofactors in prothrombin activation. J Biol Chem 278:5679-84
Majumder, Rinku; Wang, Jianfang; Lentz, Barry R (2003) Effects of water soluble phosphotidylserine on bovine factor Xa: functional and structural changes plus dimerization. Biophys J 84:1238-51
Wu, Jogin R; Zhou, Chaoming; Majumder, Rinku et al. (2002) Role of procoagulant lipids in human prothrombin activation. 1. Prothrombin activation by factor X(a) in the absence of factor V(a) and in the absence and presence of membranes. Biochemistry 41:935-49
Majumder, Rinku; Weinreb, Gabriel; Zhai, Xin et al. (2002) Soluble phosphatidylserine triggers assembly in solution of a prothrombin-activating complex in the absence of a membrane surface. J Biol Chem 277:29765-73
Srivastava, Arvind; Wang, Jianfang; Majumder, Rinku et al. (2002) Localization of phosphatidylserine binding sites to structural domains of factor Xa. J Biol Chem 277:1855-63

Showing the most recent 10 out of 27 publications