Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL045994-06A2
Application #
2222620
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1990-05-01
Project End
1999-06-30
Budget Start
1996-07-15
Budget End
1997-06-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Hawiger, J (1999) Noninvasive intracellular delivery of functional peptides and proteins. Curr Opin Chem Biol 3:89-94
Ware, S; Donahue, J P; Hawiger, J et al. (1999) Structure of the fibrinogen gamma-chain integrin binding and factor XIIIa cross-linking sites obtained through carrier protein driven crystallization. Protein Sci 8:2663-71
Hawiger, J; Veach, R A; Liu, X Y et al. (1999) IkappaB kinase complex is an intracellular target for endotoxic lipopolysaccharide in human monocytic cells. Blood 94:1711-6
Zhang, L; Torgerson, T R; Liu, X Y et al. (1998) Preparation of functionally active cell-permeable peptides by single-step ligation of two peptide modules. Proc Natl Acad Sci U S A 95:9184-9
Chu, Z L; DiDonato, J A; Hawiger, J et al. (1998) The tax oncoprotein of human T-cell leukemia virus type 1 associates with and persistently activates IkappaB kinases containing IKKalpha and IKKbeta. J Biol Chem 273:15891-4
Hawiger, J (1997) Cellular import of functional peptides to block intracellular signaling. Curr Opin Immunol 9:189-94
Liu, K Y; Timmons, S; Lin, Y Z et al. (1996) Identification of a functionally important sequence in the cytoplasmic tail of integrin beta 3 by using cell-permeable peptide analogs. Proc Natl Acad Sci U S A 93:11819-24
Lin, Y Z; Yao, S Y; Hawiger, J (1996) Role of the nuclear localization sequence in fibroblast growth factor-1-stimulated mitogenic pathways. J Biol Chem 271:5305-8
Donald, R; Ballard, D W; Hawiger, J (1995) Proteolytic processing of NF-kappa B/I kappa B in human monocytes. ATP-dependent induction by pro-inflammatory mediators. J Biol Chem 270:9-12
Blumenstein, M; Matsueda, G R; Timmons, S et al. (1992) A beta-turn is present in the 392-411 segment of the human fibrinogen gamma-chain. Effects of structural changes in this segment on affinity to antibody 4A5. Biochemistry 31:10692-8

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