Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL046440-05A1
Application #
2222923
Study Section
Lung Biology and Pathology Study Section (LBPA)
Project Start
1991-05-01
Project End
2000-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Utah
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Salt Lake City
State
UT
Country
United States
Zip Code
84112
Silverman, Edwin K; Palmer, Lyle J; Mosley, Jonathan D et al. (2002) Genomewide linkage analysis of quantitative spirometric phenotypes in severe early-onset chronic obstructive pulmonary disease. Am J Hum Genet 70:1229-39
Wencker, M; Marx, A; Konietzko, N et al. (2002) Screening for alpha1-Pi deficiency in patients with lung diseases. Eur Respir J 20:319-24
Silverman, Edwin K; Mosley, Jonathan D; Palmer, Lyle J et al. (2002) Genome-wide linkage analysis of severe, early-onset chronic obstructive pulmonary disease: airflow obstruction and chronic bronchitis phenotypes. Hum Mol Genet 11:623-32
Silverman, E K; Mosley, J D; Rao, D C et al. (2001) Linkage analysis of alpha 1-antitrypsin deficiency: lessons for complex diseases. Hum Hered 52:223-32
Campbell, E J; Campbell, M A; Owen, C A (2000) Bioactive proteinase 3 on the cell surface of human neutrophils: quantification, catalytic activity, and susceptibility to inhibition. J Immunol 165:3366-74
Campbell, E J (2000) Animal models of emphysema: the next generations. J Clin Invest 106:1445-6
Morrison, H M; Welgus, H G; Owen, C A et al. (1999) Interaction between leukocyte elastase and elastin: quantitative and catalytic analyses. Biochim Biophys Acta 1430:179-90
Campbell, E J; Campbell, M A; Boukedes, S S et al. (1999) Quantum proteolysis by neutrophils: implications for pulmonary emphysema in alpha 1-antitrypsin deficiency. J Clin Invest 104:337-44
Owen, C A; Campbell, E J (1999) The cell biology of leukocyte-mediated proteolysis. J Leukoc Biol 65:137-50
Owen, C A; Campbell, E J (1999) Extracellular proteolysis: new paradigms for an old paradox. J Lab Clin Med 134:341-51

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