Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL046494-05
Application #
2222988
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1992-02-01
Project End
1997-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
5
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of South Alabama
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Mobile
State
AL
Country
United States
Zip Code
36688
Zhu, Bing; Kelly, John; Vemavarapu, Lakshmi et al. (2004) Activation and induction of cyclic AMP phosphodiesterase (PDE4) in rat pulmonary microvascular endothelial cells. Biochem Pharmacol 68:479-91
Tarpey, Siobhan B; Sawmiller, Darrell R; Kelly, Claire et al. (2003) Phosphodiesterase 3 activity is reduced in dog lung following pacing-induced heart failure. Am J Physiol Lung Cell Mol Physiol 284:L766-73
Liu, Li; Underwood, Tashandra; Li, Han et al. (2002) Specific cGMP binding by the cGMP binding domains of cGMP-binding cGMP specific phosphodiesterase. Cell Signal 14:45-51
Thompson, W Joseph; Ashikaga, Takashi; Kelly, John J et al. (2002) Regulation of cyclic AMP in rat pulmonary microvascular endothelial cells by rolipram-sensitive cyclic AMP phosphodiesterase (PDE4). Biochem Pharmacol 63:797-807
Francis, Sharron H; Bessay, Emmanuel P; Kotera, Jun et al. (2002) Phosphorylation of isolated human phosphodiesterase-5 regulatory domain induces an apparent conformational change and increases cGMP binding affinity. J Biol Chem 277:47581-7
Liu, L; Li, H; Underwood, T et al. (2001) Cyclic GMP-dependent protein kinase activation and induction by exisulind and CP461 in colon tumor cells. J Pharmacol Exp Ther 299:583-92
Stevens, T; Creighton, J; Thompson, W J (1999) Control of cAMP in lung endothelial cell phenotypes. Implications for control of barrier function. Am J Physiol 277:L119-26
Zhou, L; Thompson, W J; Potter, D E (1999) Multiple cyclic nucleotide phosphodiesterases in human trabecular meshwork cells. Invest Ophthalmol Vis Sci 40:1745-52
Moore, T M; Chetham, P M; Kelly, J J et al. (1998) Signal transduction and regulation of lung endothelial cell permeability. Interaction between calcium and cAMP. Am J Physiol 275:L203-22
Kelly, J J; Moore, T M; Babal, P et al. (1998) Pulmonary microvascular and macrovascular endothelial cells: differential regulation of Ca2+ and permeability. Am J Physiol 274:L810-9

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