Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL046558-04
Application #
2223056
Study Section
Experimental Cardiovascular Sciences Study Section (ECS)
Project Start
1991-04-01
Project End
1997-06-30
Budget Start
1994-07-01
Budget End
1997-06-30
Support Year
4
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Physiology
Type
Schools of Medicine
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
Katakam, Prasad V G; Jordan, James E; Snipes, James A et al. (2007) Myocardial preconditioning against ischemia-reperfusion injury is abolished in Zucker obese rats with insulin resistance. Am J Physiol Regul Integr Comp Physiol 292:R920-6
Mayanagi, Keita; Gaspar, Tamas; Katakam, Prasad V G et al. (2007) The mitochondrial K(ATP) channel opener BMS-191095 reduces neuronal damage after transient focal cerebral ischemia in rats. J Cereb Blood Flow Metab 27:348-55
Csordas, Attila; Pankotai, Eszter; Snipes, James A et al. (2007) Human heart mitochondria do not produce physiologically relevant quantities of nitric oxide. Life Sci 80:633-7
Horvath, Eszter M; Lacza, Zsombor; Csordas, Attila et al. (2006) Graft derived cells with double nuclei in the penumbral region of experimental brain trauma. Neurosci Lett 396:182-6
Erdos, Benedek; Snipes, James A; Tulbert, Christina D et al. (2006) Rosuvastatin improves cerebrovascular function in Zucker obese rats by inhibiting NAD(P)H oxidase-dependent superoxide production. Am J Physiol Heart Circ Physiol 290:H1264-70
Lacza, Zsombor; Kozlov, Andrey V; Pankotai, Eszter et al. (2006) Mitochondria produce reactive nitrogen species via an arginine-independent pathway. Free Radic Res 40:369-78
Katakam, Prasad V G; Snipes, James A; Tulbert, Christina D et al. (2006) Impaired endothelin-induced vasoconstriction in coronary arteries of Zucker obese rats is associated with uncoupling of [Ca2+]i signaling. Am J Physiol Regul Integr Comp Physiol 290:R145-53
Lacza, Zsombor; Pankotai, Eszter; Csordas, Attila et al. (2006) Mitochondrial NO and reactive nitrogen species production: does mtNOS exist? Nitric Oxide 14:162-8
Gaspar, Tamas; Kis, Bela; Snipes, James A et al. (2006) Transient glucose and amino acid deprivation induces delayed preconditioning in cultured rat cortical neurons. J Neurochem 98:555-65
Horiguchi, T; Snipes, J A; Kis, B et al. (2006) Cyclooxygenase-2 mediates the development of cortical spreading depression-induced tolerance to transient focal cerebral ischemia in rats. Neuroscience 140:723-30

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