Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL046763-03
Application #
2223191
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1993-01-01
Project End
1996-12-31
Budget Start
1995-01-01
Budget End
1996-12-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Janin, Y; Qian, Y Z; Hoag, J B et al. (1998) Pharmacologic preconditioning with monophosphoryl lipid A is abolished by 5-hydroxydecanoate, a specific inhibitor of the K(ATP) channel. J Cardiovasc Pharmacol 32:337-42
Nayeem, M A; Hess, M L; Qian, Y Z et al. (1997) Delayed preconditioning of cultured adult rat cardiac myocytes: role of 70- and 90-kDa heat stress proteins. Am J Physiol 273:H861-8
Hoag, J B; Qian, Y Z; Nayeem, M A et al. (1997) ATP-sensitive potassium channel mediates delayed ischemic protection by heat stress in rabbit heart. Am J Physiol 273:H2458-64
Schultz, J E; Qian, Y Z; Gross, G J et al. (1997) The ischemia-selective KATP channel antagonist, 5-hydroxydecanoate, blocks ischemic preconditioning in the rat heart. J Mol Cell Cardiol 29:1055-60
Nayeem, M A; Elliott, G T; Shah, M R et al. (1997) Monophosphoryl lipid A protects adult rat cardiac myocytes with induction of the 72-kD heat shock protein: a cellular model of pharmacologic preconditioning. J Mol Cell Cardiol 29:2305-10
Kukreja, R C; Kontos, M C; Hess, M L (1996) Free radicals and heat shock protein in the heart. Ann N Y Acad Sci 793:108-22
Yoshida, K; Maaieh, M M; Shipley, J B et al. (1996) Monophosphoryl lipid A induces pharmacologic 'preconditioning' in rabbit hearts without concomitant expression of 70-kDa heat shock protein. Mol Cell Biochem 156:1-8
Yoshida, K; Maaieh, M M; Shipley, J B et al. (1996) Monophosphoryl lipid A induces pharmacologic 'preconditioning' in rabbit hearts without concomitant expression of 70-kDa heat shock protein. Mol Cell Biochem 159:73-80
Pathak, S K; Kukreja, R C; Hess, M (1996) Molecular Pathology of Dilated Cardiomyopathies. Curr Probl Cardiol 21:99-144
Kontos, M C; Shipley, J B; Kukreja, R C (1996) Heat stress improves functional recovery and induces synthesis of 27- and 70-kDa heat shock proteins without preserving sarcoplasmic reticulum function in the ischemic rat heart. J Mol Cell Cardiol 28:1885-94

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