Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL046843-04A1
Application #
2223243
Study Section
Special Emphasis Panel (ZRG4-ECS (01))
Project Start
1991-08-01
Project End
2001-03-31
Budget Start
1996-04-05
Budget End
1997-03-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of California Los Angeles
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
119132785
City
Los Angeles
State
CA
Country
United States
Zip Code
90095
Shah, S; Nathan, L; Singh, R et al. (2001) E2 and not P4 increases NO release from NANC nerves of the gastrointestinal tract: implications in pregnancy. Am J Physiol Regul Integr Comp Physiol 280:R1546-54
Nathan, L; Shi, W; Dinh, H et al. (2001) Testosterone inhibits early atherogenesis by conversion to estradiol: critical role of aromatase. Proc Natl Acad Sci U S A 98:3589-93
Singh, R; Pervin, S; Karimi, A et al. (2000) Arginase activity in human breast cancer cell lines: N(omega)-hydroxy-L-arginine selectively inhibits cell proliferation and induces apoptosis in MDA-MB-468 cells. Cancer Res 60:3305-12
Singh, R; Pervin, S; Shryne, J et al. (2000) Castration increases and androgens decrease nitric oxide synthase activity in the brain: physiologic implications. Proc Natl Acad Sci U S A 97:3672-7
Shah, S; Hobbs, A; Singh, R et al. (2000) Gastrointestinal motility during pregnancy: role of nitrergic component of NANC nerves. Am J Physiol Regul Integr Comp Physiol 279:R1478-85
Nathan, L; Pervin, S; Singh, R et al. (1999) Estradiol inhibits leukocyte adhesion and transendothelial migration in rabbits in vivo : possible mechanisms for gender differences in atherosclerosis. Circ Res 85:377-85
Grewal, M; Cuevas, J; Chaudhuri, G et al. (1999) Effects of calcitonin gene-related peptide on vascular resistance in rats: role of sex steroids. Am J Physiol 276:H2063-8
Hyun, J; Chaudhuri, G; Fukuto, J M (1999) The reductive metabolism of nitric oxide in hepatocytes: possible interaction with thiols. Drug Metab Dispos 27:1005-9
Pervin, S; Singh, R; Rosenfeld, M E et al. (1998) Estradiol suppresses MCP-1 expression In vivo : implications for atherosclerosis. Arterioscler Thromb Vasc Biol 18:1575-82
Nathan, L; Chaudhuri, G (1997) Estrogens and atherosclerosis. Annu Rev Pharmacol Toxicol 37:477-515

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