Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL047032-01A3S1
Application #
878020
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1994-08-01
Project End
1999-07-31
Budget Start
1994-08-01
Budget End
1995-07-31
Support Year
1
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Beth Israel Deaconess Medical Center
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02215
Ashton, Anthony W; Cheng, Yan; Helisch, Armin et al. (2004) Thromboxane A2 receptor agonists antagonize the proangiogenic effects of fibroblast growth factor-2: role of receptor internalization, thrombospondin-1, and alpha(v)beta3. Circ Res 94:735-42
Ashton, Anthony W; Ware, J Anthony (2004) Thromboxane A2 receptor signaling inhibits vascular endothelial growth factor-induced endothelial cell differentiation and migration. Circ Res 95:372-9
Ashton, Anthony W; Ware, Gabriel M; Kaul, Dhananjaya K et al. (2003) Inhibition of tumor necrosis factor alpha-mediated NFkappaB activation and leukocyte adhesion, with enhanced endothelial apoptosis, by G protein-linked receptor (TP) ligands. J Biol Chem 278:11858-66
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Harrington, E O; Doyle, K E; Brunelle, J L et al. (2000) Endothelial proliferation, migration, and differentiation are blunted by conditionally expressed protein kinase C pseudosubstrate peptides. Biochem Biophys Res Commun 271:499-508
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Ashton, A W; Yokota, R; John, G et al. (1999) Inhibition of endothelial cell migration, intercellular communication, and vascular tube formation by thromboxane A(2). J Biol Chem 274:35562-70
Shizukuda, Y; Tang, S; Yokota, R et al. (1999) Vascular endothelial growth factor-induced endothelial cell migration and proliferation depend on a nitric oxide-mediated decrease in protein kinase Cdelta activity. Circ Res 85:247-56
Ashton, A W; Watanabe, G; Albanese, C et al. (1999) Protein kinase Cdelta inhibition of S-phase transition in capillary endothelial cells involves the cyclin-dependent kinase inhibitor p27(Kip1). J Biol Chem 274:20805-11

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