A five year study is proposed to develop, test and apply comprehensive models for the interaction of genetic and environmental effect on cardiovascular risk with gender differences. Models will be developed which allow for sex difference in the expression of autosomal polygenes, differences in the impact of the paternal and maternal environment on male and female offspring, and for the complex consequences of assortative mating on the correlations among loci and between genes and environment. Computer simulations will be used to decide which kinds of gender-dependent effects can be resolved with particular constellations of relatives, and to address problems of power and bias resulting from errors of model-specification. The methods developed will be applied to data from extensive data already gathered from twins and their relatives to determine the importance of sex differences in genetic and environmental causes of variation in measured aspects of cardiovascular risk including weight, body-mass index, family history of CV disease, smoking, alcohol consumption, exercise, diet, psychosocial variables and lifestyle.
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| Deng, Xiaodi; Morris, Jamie; Dressmen, James et al. (2012) The structure of dimeric apolipoprotein A-IV and its mechanism of self-association. Structure 20:767-79 |
| Sorci-Thomas, Mary G; Owen, John S; Fulp, Brian et al. (2012) Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers. J Lipid Res 53:1890-909 |
| Huang, Rong; Silva, R A Gangani D; Jerome, W Gray et al. (2011) Apolipoprotein A-I structural organization in high-density lipoproteins isolated from human plasma. Nat Struct Mol Biol 18:416-22 |
| Silva, R A Gangani D; Huang, Rong; Morris, Jamie et al. (2008) Structure of apolipoprotein A-I in spherical high density lipoproteins of different sizes. Proc Natl Acad Sci U S A 105:12176-81 |
| Jerome, W Gray; Cox, Brian E; Griffin, Evelyn E et al. (2008) Lysosomal cholesterol accumulation inhibits subsequent hydrolysis of lipoprotein cholesteryl ester. Microsc Microanal 14:138-49 |
| Yancey, Patricia G; Jerome, W Gray; Yu, Hong et al. (2007) Severely altered cholesterol homeostasis in macrophages lacking apoE and SR-BI. J Lipid Res 48:1140-9 |
| D'Onofrio, Brian M; Turkheimer, Eric; Emery, Robert E et al. (2007) A Children of Twins Study of parental divorce and offspring psychopathology. J Child Psychol Psychiatry 48:667-75 |
| Turkheimer, Eric; D'Onofrio, Brian M; Maes, Hermine H et al. (2005) Analysis and interpretation of twin studies including measures of the shared environment. Child Dev 76:1217-33 |
| Bulik, C M; Wade, T D; Heath, A C et al. (2001) Relating body mass index to figural stimuli: population-based normative data for Caucasians. Int J Obes Relat Metab Disord 25:1517-24 |
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