Repressors of Human E and Gamma Globin Gene Expression - Deborah Gumucio

Abstract

Funding Agency

Agency: National Institute of Health (NIH)
Institute: National Heart, Lung, and Blood Institute (NHLBI)
Type: Research Project (R01)
Project #: 5R01HL048802-04
Application #: 2224887
Study Section: Hematology Subcommittee 2 (HEM)

Project Start: 1993-04-01
Project End: 1998-03-31
Budget Start: 1996-04-01
Budget End: 1998-03-31
Support Year: 4
Fiscal Year: 1996
Total Cost
Indirect Cost

Institution

Name: University of Michigan Ann Arbor
Department: Anatomy/Cell Biology
Type: Schools of Medicine
DUNS #: 791277940

City: Ann Arbor
State: MI
Country: United States
Zip Code: 48109

Related projects


NIH 2001 R01 HL	Repressors of Human and Globin Gene Expression Gumucio, Deborah L. / University of Michigan Ann Arbor	$326,181
NIH 2000 R01 HL	Repressors of Human and Globin Gene Expression Gumucio, Deborah L. / University of Michigan Ann Arbor	$316,678
NIH 1999 R01 HL	Repressors of Human and Globin Gene Expression Gumucio, Deborah L. / University of Michigan Ann Arbor
NIH 1998 R01 HL	Repressors of Human and Globin Gene Expression Gumucio, Deborah L. / University of Michigan Ann Arbor
NIH 1996 R01 HL	Repressors of Human E and Gamma Globin Gene Expression Gumucio, Deborah L. / University of Michigan Ann Arbor
NIH 1995 R01 HL	Repressors of Human E and Gamma Globin Gene Expression Gumucio, Deborah L. / University of Michigan Ann Arbor
NIH 1994 R01 HL	Repressors of Human E and Gamma Globin Gene Expression Gumucio, Deborah L. / University of Michigan Ann Arbor
NIH 1993 R01 HL	Repressors of Human E and Gamma Globin Gene Expression Gumucio, Deborah L. / University of Michigan Ann Arbor

Publications

Yu, Timothy; Thomas, David M; Zhu, Wei et al. (2002) Regulation of fetal versus embryonic gamma globin genes: appropriate developmental stage expression patterns in the presence of HS2 of the locus control region. Blood 99:1082-4

Zhu, W; TomHon, C; Mason, M et al. (1999) Analysis of linked human epsilon and gamma transgenes: effect of locus control region hypersensitive sites 2 and 3 or a distal YY1 mutation on stage-specific expression patterns. Blood 93:3540-9

TomHon, C; Zhu, W; Millinoff, D et al. (1997) Evolution of a fetal expression pattern via cis changes near the gamma globin gene. J Biol Chem 272:14062-6

Shelton, D A; Stegman, L; Hardison, R et al. (1997) Phylogenetic footprinting of hypersensitive site 3 of the beta-globin locus control region. Blood 89:3457-69

Gumucio, D L; Shelton, D A; Zhu, W et al. (1996) Evolutionary strategies for the elucidation of cis and trans factors that regulate the developmental switching programs of the beta-like globin genes. Mol Phylogenet Evol 5:18-32

Yant, S R; Zhu, W; Millinoff, D et al. (1995) High affinity YY1 binding motifs: identification of two core types (ACAT and CCAT) and distribution of potential binding sites within the human beta globin cluster. Nucleic Acids Res 23:4353-62

Zhu, W; Lossie, A C; Camper, S A et al. (1994) Chromosomal localization of the transcription factor YY1 in the mouse and human. Mamm Genome 5:234-6

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