Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL049122-03
Application #
2225227
Study Section
Physiological Chemistry Study Section (PC)
Project Start
1994-05-01
Project End
1999-04-30
Budget Start
1996-05-01
Budget End
1997-04-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Rice University
Department
Biochemistry
Type
Schools of Arts and Sciences
DUNS #
050299031
City
Houston
State
TX
Country
United States
Zip Code
77005
Guo, Li-Wei; Wilson, William K; Pang, Jihai et al. (2003) Chemical synthesis of 7- and 8-dehydro derivatives of pregnane-3,17alpha,20-triols, potential steroid metabolites in Smith-Lemli-Opitz syndrome. Steroids 68:31-42
Shan, Hui; Pang, Jihai; Li, Shengrong et al. (2003) Chromatographic behavior of oxygenated derivatives of cholesterol. Steroids 68:221-33
Xu, Ran; Wilson, William K; Matsuda, Seiichi P T (2002) Production of meiosis-activating sterols from metabolically engineered yeast. J Am Chem Soc 124:918-9
Xiong, Quanbo; Ruan, Benfang; Whitby, Frank G et al. (2002) A colorimetric assay for 7-dehydrocholesterol with potential application to screening for Smith-Lemli-Opitz syndrome. Chem Phys Lipids 115:1-15
Shan, Hui; Wilson, William K (2002) Ternary gradient elution markedly improves silver-ion high performance liquid chromatography of unsaturated sterols. Steroids 67:917-23
Ruan, Benfang; Lai, Peggy S; Yeh, Christine W et al. (2002) Alternative pathways of sterol synthesis in yeast. Use of C(27) sterol tracers to study aberrant double-bond migrations and evaluate their relative importance. Steroids 67:1109-19
Ruan, B; Wilson, W K; Pang, J et al. (2001) Sterols in blood of normal and Smith-Lemli-Opitz subjects. J Lipid Res 42:799-812
Downs, S M; Ruan, B; Schroepfer Jr, G J (2001) Meiosis-activating sterol and the maturation of isolated mouse oocytes. Biol Reprod 64:80-9
Gardner, R G; Shan, H; Matsuda, S P et al. (2001) An oxysterol-derived positive signal for 3-hydroxy- 3-methylglutaryl-CoA reductase degradation in yeast. J Biol Chem 276:8681-94
Lindenthal, B; Holleran, A L; Aldaghlas, T A et al. (2001) Progestins block cholesterol synthesis to produce meiosis-activating sterols. FASEB J 15:775-84

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