Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL049434-03
Application #
2225527
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1993-12-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Lin, Kurt M; Hollander, John M; Kao, Vivia Y et al. (2004) Myocyte protection by 10 kD heat shock protein (Hsp10) involves the mobile loop and attenuation of the Ras GTP-ase pathway. FASEB J 18:1004-6
Hollander, John M; Martin, Jody L; Belke, Darrell D et al. (2004) Overexpression of wild-type heat shock protein 27 and a nonphosphorylatable heat shock protein 27 mutant protects against ischemia/reperfusion injury in a transgenic mouse model. Circulation 110:3544-52
Andrews, Catherine; Ho, Peter D; Dillmann, Wolfgang H et al. (2003) The MKK6-p38 MAPK pathway prolongs the cardiac contractile calcium transient, downregulates SERCA2, and activates NF-AT. Cardiovasc Res 59:46-56
Hollander, John M; Lin, Kurt M; Scott, Brian T et al. (2003) Overexpression of PHGPx and HSP60/10 protects against ischemia/reoxygenation injury. Free Radic Biol Med 35:742-51
Ray, P S; Martin, J L; Swanson, E A et al. (2001) Transgene overexpression of alphaB crystallin confers simultaneous protection against cardiomyocyte apoptosis and necrosis during myocardial ischemia and reperfusion. FASEB J 15:393-402
Lin, K M; Lin, B; Lian, I Y et al. (2001) Combined and individual mitochondrial HSP60 and HSP10 expression in cardiac myocytes protects mitochondrial function and prevents apoptotic cell deaths induced by simulated ischemia-reoxygenation. Circulation 103:1787-92
Meyer, M; Trost, S U; Bluhm, W F et al. (2001) Impaired sarcoplasmic reticulum function leads to contractile dysfunction and cardiac hypertrophy. Am J Physiol Heart Circ Physiol 280:H2046-52
Martin, J L; Hickey, E; Weber, L A et al. (1999) Influence of phosphorylation and oligomerization on the protective role of the small heat shock protein 27 in rat adult cardiomyocytes. Gene Expr 7:349-55
Meyer, M; Bluhm, W F; He, H et al. (1999) Phospholamban-to-SERCA2 ratio controls the force-frequency relationship. Am J Physiol 276:H779-85
Bluhm, W F; Martin, J L; Mestril, R et al. (1998) Specific heat shock proteins protect microtubules during simulated ischemia in cardiac myocytes. Am J Physiol 275:H2243-9

Showing the most recent 10 out of 13 publications