Regulation of Tgf-Beta Activity by Thrombospondin

Murphy-Ullrich, Joanne E.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 5R01HL050061-03
• Application #: 2226173
• Study Section: Pathobiochemistry Study Section (PBC)
• Project Start: 1994-07-01
• Project End: 1999-06-30
• Budget Start: 1996-07-01
• Budget End: 1997-06-30
• Support Year: 3
• Fiscal Year: 1996

Institution

• Name: University of Alabama Birmingham
• Department: Pathology
• Type: Schools of Dentistry
• DUNS #: 004514360
• City: Birmingham
• State: AL
• Country: United States
• Zip Code: 35294

Publications

Belmadani, Souad; Bernal, Juan; Wei, Chih-Chang et al. (2007) A thrombospondin-1 antagonist of transforming growth factor-beta activation blocks cardiomyopathy in rats with diabetes and elevated angiotensin II. Am J Pathol 171:777-89

Zhou, Yong; Poczatek, Maria H; Berecek, Kathleen H et al. (2006) Thrombospondin 1 mediates angiotensin II induction of TGF-beta activation by cardiac and renal cells under both high and low glucose conditions. Biochem Biophys Res Commun 339:633-41

Young, Geoffrey D; Murphy-Ullrich, Joanne E (2004) The tryptophan-rich motifs of the thrombospondin type 1 repeats bind VLAL motifs in the latent transforming growth factor-beta complex. J Biol Chem 279:47633-42

Daniel, Christoph; Wiede, Julia; Krutzsch, Henry C et al. (2004) Thrombospondin-1 is a major activator of TGF-beta in fibrotic renal disease in the rat in vivo. Kidney Int 65:459-68

Young, Geoffrey D; Murphy-Ullrich, Joanne E (2004) Molecular interactions that confer latency to transforming growth factor-beta. J Biol Chem 279:38032-9

Zhang, Hong; Akman, Hasan O; Smith, Eric L P et al. (2003) Cellular response to hypoxia involves signaling via Smad proteins. Blood 101:2253-60

Wang, Shuxia; Shiva, Sruti; Poczatek, Maria H et al. (2002) Nitric oxide and cGMP-dependent protein kinase regulation of glucose-mediated thrombospondin 1-dependent transforming growth factor-beta activation in mesangial cells. J Biol Chem 277:9880-8

Harpel, J G; Schultz-Cherry, S; Murphy-Ullrich, J E et al. (2001) Tamoxifen and estrogen effects on TGF-beta formation: role of thrombospondin-1, alphavbeta3, and integrin-associated protein. Biochem Biophys Res Commun 284:11-4

Murphy-Ullrich, J E; Poczatek, M (2000) Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology. Cytokine Growth Factor Rev 11:59-69

Patel, R P; Moellering, D; Murphy-Ullrich, J et al. (2000) Cell signaling by reactive nitrogen and oxygen species in atherosclerosis. Free Radic Biol Med 28:1780-94