Platelet and Endothelial Cell C1 Receptors

Peerschke, Ellinor I.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Heart, Lung, and Blood Institute (NHLBI)
• Type: Research Project (R01)
• Project #: 5R01HL050291-02
• Application #: 2226445
• Study Section: Hematology Subcommittee 2 (HEM)
• Project Start: 1995-09-01
• Project End: 1996-10-31
• Budget Start: 1996-08-01
• Budget End: 1996-10-31
• Support Year: 2
• Fiscal Year: 1996

Institution

• Name: State University New York Stony Brook
• Department: Pathology
• Type: Schools of Medicine
• DUNS #: 804878247
• City: Stony Brook
• State: NY
• Country: United States
• Zip Code: 11794

Publications

Bossi, Fleur; Fischetti, Fabio; Regoli, Domenico et al. (2009) Novel pathogenic mechanism and therapeutic approaches to angioedema associated with C1 inhibitor deficiency. J Allergy Clin Immunol 124:1303-10.e4

Ghebrehiwet, Berhane; Feng, Xiaodong; Kumar, Rajeev et al. (2003) Complement component C1q induces endothelial cell adhesion and spreading through a docking/signaling partnership of C1q receptors and integrins. Int Immunopharmacol 3:299-310

Kumar, Rajeev; Peerschke, Ellinor I B; Ghebrehiwet, Berhane (2002) Zinc induces exposure of hydrophobic sites in the C-terminal domain of gC1q-R/p33. Mol Immunol 39:69-75

Feng, Xiaodong; Tonnesen, Marcia G; Peerschke, Ellinor I B et al. (2002) Cooperation of C1q receptors and integrins in C1q-mediated endothelial cell adhesion and spreading. J Immunol 168:2441-8

Ghebrehiwet, Berhane; Jesty, Jolyon; Peerschke, Ellinor I B (2002) gC1q-R/p33: structure-function predictions from the crystal structure. Immunobiology 205:421-32

Szabo, J; Cervenak, L; Toth, F D et al. (2001) Soluble gC1q-R/p33, a cell protein that binds to the globular ""heads"" of C1q, effectively inhibits the growth of HIV-1 strains in cell cultures. Clin Immunol 99:222-31

Peerschke, E I; Ghebrehiwet, B (2001) Human blood platelet gC1qR/p33. Immunol Rev 180:56-64

Nguyen, T; Ghebrehiwet, B; Peerschke, E I (2000) Staphylococcus aureus protein A recognizes platelet gC1qR/p33: a novel mechanism for staphylococcal interactions with platelets. Infect Immun 68:2061-8

Peerschke, E I (1999) Maintenance of GPIIb-IIIa avidity supporting ""irreversible"" fibrinogen binding is energy-dependent. J Lab Clin Med 134:398-404

Lu, P D; Galanakis, D K; Ghebrehiwet, B et al. (1999) The receptor for the globular ""heads"" of C1q, gC1q-R, binds to fibrinogen/fibrin and impairs its polymerization. Clin Immunol 90:360-7