Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL051005-03
Application #
2227367
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1994-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Texas Austin
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
City
Austin
State
TX
Country
United States
Zip Code
78712
Biswal, S S; Datta, K; Kehrer, J P (2001) Association between bcl-x(L) and 5-lipoxygenase activating protein (FLAP) levels in IL-3-dependent FL5.12 cells. Toxicology 160:97-103
Datta, K; Kern, J C; Biswal, S S et al. (2001) Proteolytic loss of bcl-x(L) in FL5.12 Cells undergoing apoptosis induced by MK886. Toxicol Appl Pharmacol 174:273-81
Biswal, S S; Datta, K; Shaw, S D et al. (2000) Glutathione oxidation and mitochondrial depolarization as mechanisms of nordihydroguaiaretic acid-induced apoptosis in lipoxygenase-deficient FL5.12 cells. Toxicol Sci 53:77-83
Kehrer, J P (2000) The Haber-Weiss reaction and mechanisms of toxicity. Toxicology 149:43-50
Seiler, K S; Starnes, J W (2000) Exogenous GSH protection during hypoxia-reoxygenation of the isolated rat heart: impact of hypoxia duration. Free Radic Res 32:41-55
Bojes, H K; Feng, X; Kehrer, J P et al. (1999) Apoptosis in hematopoietic cells (FL5.12) caused by interleukin-3 withdrawal: relationship to caspase activity and the loss of glutathione. Cell Death Differ 6:61-70
Datta, K; Biswal, S S; Kehrer, J P (1999) The 5-lipoxygenase-activating protein (FLAP) inhibitor, MK886, induces apoptosis independently of FLAP. Biochem J 340 ( Pt 2):371-5
Robertson, J D; Datta, K; Biswal, S S et al. (1999) Heat-shock protein 70 antisense oligomers enhance proteasome inhibitor-induced apoptosis. Biochem J 344 Pt 2:477-85
Bojes, H K; Suresh, P K; Mills, E M et al. (1998) Bcl-2 and Bcl-xL in peroxide-resistant A549 and U87MG cells. Toxicol Sci 42:109-16
Swift Jr, J N; Kehrer, J P; Seiler, K S et al. (1998) Vitamin E concentration in rat skeletal muscle and liver after exercise. Int J Sport Nutr 8:105-12

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