Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL051090-03
Application #
2227603
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1993-12-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Virginia Commonwealth University
Department
Surgery
Type
Schools of Medicine
DUNS #
City
Richmond
State
VA
Country
United States
Zip Code
23298
Abd-Elfattah, Anwar Saad; Tuchy, Gert E; Jessen, Michael E et al. (2013) Hot shot induction and reperfusion with a specific blocker of the es-ENT1 nucleoside transporter before and after hypothermic cardioplegia abolishes myocardial stunning in acutely ischemic hearts despite metabolic derangement: hot shot drug delivery befor J Thorac Cardiovasc Surg 146:961-970.e3
Abd-Elfattah, Anwar Saad; Aly, Hamdy; Hanan, Scott et al. (2012) Myocardial protection in beating heart cardiac surgery: I: pre- or postconditioning with inhibition of es-ENT1 nucleoside transporter and adenosine deaminase attenuates post-MI reperfusion-mediated ventricular fibrillation and regional contractile dysfunc J Thorac Cardiovasc Surg 144:250-5
Abd-Elfattah, Anwar Saad; Ding, Mai; Jessen, Michael E et al. (2012) On-pump inhibition of es-ENT1 nucleoside transporter and adenosine deaminase during aortic crossclamping entraps intracellular adenosine and protects against reperfusion injury: role of adenosine A1 receptor. J Thorac Cardiovasc Surg 144:243-9
Mahgoub, M A; Guo, J H; Gao, S P et al. (1999) Hyperdynamic circulation of arteriovenous fistula preconditions the heart and limits infarct size. Ann Thorac Surg 68:22-8
Abd-Elfattah, A S; Hoehner, J; Wechsler, A S (1998) Identification of nucleoside transport binding sites in the human myocardium. Mol Cell Biochem 180:105-10
Abd-Elfattah, A S; Maddox, R P; Jessen, M E et al. (1998) Role of nucleoside transport and purine release in a rabbit model of myocardial stunning. Mol Cell Biochem 180:145-51
Abd-Elfattah, A S; Ding, M; Wechsler, A S (1995) Intermittent aortic crossclamping prevents cumulative adenosine triphosphate depletion, ventricular fibrillation, and dysfunction (stunning): is it preconditioning? J Thorac Cardiovasc Surg 110:328-39
Abd-Elfattah, A S; Wechsler, A S (1995) Myocardial preconditioning: a model or a phenomenon? J Card Surg 10:381-8