Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL051197-01S1
Application #
839117
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1994-04-09
Project End
1999-03-31
Budget Start
1994-04-09
Budget End
1995-03-31
Support Year
1
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Pharmacology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Johnson Jr, J P; Balser, J R; Bennett, P B (2001) A novel extracellular calcium sensing mechanism in voltage-gated potassium ion channels. J Neurosci 21:4143-53
Johnson Jr, J P; Mullins, F M; Bennett, P B (1999) Human ether-a-go-go-related gene K+ channel gating probed with extracellular ca2+. Evidence for two distinct voltage sensors. J Gen Physiol 113:565-80
Po, S S; Wang, D W; Yang, I C et al. (1999) Modulation of HERG potassium channels by extracellular magnesium and quinidine. J Cardiovasc Pharmacol 33:181-5
Wang, D W; VanDeCarr, D; Ruben, P C et al. (1999) Functional consequences of a domain 1/S6 segment sodium channel mutation associated with painful congenital myotonia. FEBS Lett 448:231-4
London, B; Wang, D W; Hill, J A et al. (1998) The transient outward current in mice lacking the potassium channel gene Kv1.4. J Physiol 509 ( Pt 1):171-82
Wang, D W; Yazawa, K; Makita, N et al. (1997) Pharmacological targeting of long QT mutant sodium channels. J Clin Invest 99:1714-20
Wang, D W; George Jr, A L; Bennett, P B (1996) Comparison of heterologously expressed human cardiac and skeletal muscle sodium channels. Biophys J 70:238-45
Makita, N; Bennett Jr, P B; George Jr, A L (1996) Multiple domains contribute to the distinct inactivation properties of human heart and skeletal muscle Na+ channels. Circ Res 78:244-52
Wang, D W; Nie, L; George Jr, A L et al. (1996) Distinct local anesthetic affinities in Na+ channel subtypes. Biophys J 70:1700-8
Wang, D W; Yazawa, K; George Jr, A L et al. (1996) Characterization of human cardiac Na+ channel mutations in the congenital long QT syndrome. Proc Natl Acad Sci U S A 93:13200-5

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