Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL052597-02
Application #
2230065
Study Section
Pathology A Study Section (PTHA)
Project Start
1995-08-01
Project End
1999-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Rush University Medical Center
Department
Type
DUNS #
City
Chicago
State
IL
Country
United States
Zip Code
60612
Subbaiah, Papasani V; Sowa, Jennifer M; Singh, Dev K (2008) Sphingolipids and cellular cholesterol homeostasis. Effect of ceramide on cholesterol trafficking and HMG CoA reductase activity. Arch Biochem Biophys 474:32-8
Huang, Fei; Subbaiah, Papasani V; Holian, Oksana et al. (2005) Lysophosphatidylcholine increases endothelial permeability: role of PKCalpha and RhoA cross talk. Am J Physiol Lung Cell Mol Physiol 289:L176-85
Subbaiah, Papasani V; Sowa, Jennifer M; Davidson, Michael H (2004) Evidence for altered positional specificity of LCAT in vivo: studies with docosahexaenoic acid feeding in humans. J Lipid Res 45:2245-51
Liu, Lijuan; Bortnick, Anna E; Nickel, Margaret et al. (2003) Effects of apolipoprotein A-I on ATP-binding cassette transporter A1-mediated efflux of macrophage phospholipid and cholesterol: formation of nascent high density lipoprotein particles. J Biol Chem 278:42976-84
Lum, Hazel; Qiao, Jing; Walter, Robert J et al. (2003) Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells. Am J Physiol Heart Circ Physiol 285:H1786-9
Francone, Omar L; Subbaiah, Papasani V; van Tol, Arie et al. (2003) Abnormal phospholipid composition impairs HDL biogenesis and maturation in mice lacking Abca1. Biochemistry 42:8569-78
Subbaiah, Papasani V; Billington, Stephen J; Jost, B Helen et al. (2003) Sphingomyelinase D, a novel probe for cellular sphingomyelin: effects on cholesterol homeostasis in human skin fibroblasts. J Lipid Res 44:1574-80
Sargis, Robert M; Subbaiah, Papasani V (2003) Trans unsaturated fatty acids are less oxidizable than cis unsaturated fatty acids and protect endogenous lipids from oxidation in lipoproteins and lipid bilayers. Biochemistry 42:11533-43
Wang, Kewei; Subbaiah, Papasani V (2002) Role of the interfacial binding domain in the oxidative susceptibility of lecithin:cholesterol acyltransferase. Biochem J 365:649-57
Gesquiere, Laurence; Cho, Wonhwa; Subbaiah, Papasani V (2002) Role of group IIa and group V secretory phospholipases A(2) in the metabolism of lipoproteins. Substrate specificities of the enzymes and the regulation of their activities by sphingomyelin. Biochemistry 41:4911-20

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