Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL052675-02
Application #
2230209
Study Section
Cardiovascular and Renal Study Section (CVB)
Project Start
1995-04-01
Project End
1999-02-28
Budget Start
1996-03-01
Budget End
1997-02-28
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Saint Louis University
Department
Pharmacology
Type
Schools of Medicine
DUNS #
City
Saint Louis
State
MO
Country
United States
Zip Code
63103
Ellsworth, Mary L; Ellis, Christopher G; Goldman, Daniel et al. (2009) Erythrocytes: oxygen sensors and modulators of vascular tone. Physiology (Bethesda) 24:107-16
Moreland, K Trent; Procknow, Jesse D; Sprague, Randy S et al. (2007) Cyclooxygenase (COX)-1 and COX-2 participate in 5,6-epoxyeicosatrienoic acid-induced contraction of rabbit intralobar pulmonary arteries. J Pharmacol Exp Ther 321:446-54
Liang, Griffith; Stephenson, Alan H; Lonigro, Andrew J et al. (2005) Erythrocytes of humans with cystic fibrosis fail to stimulate nitric oxide synthesis in isolated rabbit lungs. Am J Physiol Heart Circ Physiol 288:H1580-5
Losapio, Jennifer L; Sprague, Randy S; Lonigro, Andrew J et al. (2005) 5,6-EET-induced contraction of intralobar pulmonary arteries depends on the activation of Rho-kinase. J Appl Physiol 99:1391-6
Stephenson, Alan H; Sprague, Randy S; Losapio, Jennifer L et al. (2003) Differential effects of 5,6-EET on segmental pulmonary vasoactivity in the rabbit. Am J Physiol Heart Circ Physiol 284:H2153-61
Sprague, Randy S; Olearczyk, Jeffrey J; Spence, Dana M et al. (2003) Extracellular ATP signaling in the rabbit lung: erythrocytes as determinants of vascular resistance. Am J Physiol Heart Circ Physiol 285:H693-700
Sprague, R S; Bowles, E A; Olearczyk, J J et al. (2002) The role of G protein beta subunits in the release of ATP from human erythrocytes. J Physiol Pharmacol 53:667-74
Sprague, R S; Stephenson, A H; Ellsworth, M L et al. (2001) Impaired release of ATP from red blood cells of humans with primary pulmonary hypertension. Exp Biol Med (Maywood) 226:434-9
Schuster, D P; Kozlowski, J K; McCarthy, T et al. (2001) Effect of endotoxin on oleic acid lung injury does not depend on priming. J Appl Physiol 91:2047-54
Sprague, R S; Ellsworth, M L; Stephenson, A H et al. (2001) Participation of cAMP in a signal-transduction pathway relating erythrocyte deformation to ATP release. Am J Physiol Cell Physiol 281:C1158-64

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