Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL052692-02
Application #
2230234
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1994-12-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
017730458
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Mazumder, Barsanjit; Seshadri, Vasudevan; Fox, Paul L (2003) Translational control by the 3'-UTR: the ends specify the means. Trends Biochem Sci 28:91-8
Mazumder, B; Seshadri, V; Imataka, H et al. (2001) Translational silencing of ceruloplasmin requires the essential elements of mRNA circularization: poly(A) tail, poly(A)-binding protein, and eukaryotic translation initiation factor 4G. Mol Cell Biol 21:6440-9
van Aalst, J A; Pitsch, R J; Absood, A et al. (2000) Mechanism of dacron-activated monocytic cell oxidation of low density lipoprotein. J Vasc Surg 31:171-80
Mazumder, B; Fox, P L (1999) Delayed translational silencing of ceruloplasmin transcript in gamma interferon-activated U937 monocytic cells: role of the 3' untranslated region. Mol Cell Biol 19:6898-905
Attieh, Z K; Mukhopadhyay, C K; Seshadri, V et al. (1999) Ceruloplasmin ferroxidase activity stimulates cellular iron uptake by a trivalent cation-specific transport mechanism. J Biol Chem 274:1116-23
Mukhopadhyay, C K; Fox, P L (1998) Ceruloplasmin copper induces oxidant damage by a redox process utilizing cell-derived superoxide as reductant. Biochemistry 37:14222-9
Mukhopadhyay, C K; Attieh, Z K; Fox, P L (1998) Role of ceruloplasmin in cellular iron uptake. Science 279:714-7
Mukhopadhyay, C K; Mazumder, B; Lindley, P F et al. (1997) Identification of the prooxidant site of human ceruloplasmin: a model for oxidative damage by copper bound to protein surfaces. Proc Natl Acad Sci U S A 94:11546-51
Mazumder, B; Mukhopadhyay, C K; Prok, A et al. (1997) Induction of ceruloplasmin synthesis by IFN-gamma in human monocytic cells. J Immunol 159:1938-44
Mukhopadhyay, C K; Ehrenwald, E; Fox, P L (1996) Ceruloplasmin enhances smooth muscle cell- and endothelial cell-mediated low density lipoprotein oxidation by a superoxide-dependent mechanism. J Biol Chem 271:14773-8

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